Prospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Nov 5, 2021; 12(6): 103-112
Published online Nov 5, 2021. doi: 10.4292/wjgpt.v12.i6.103
Addition of castor oil as a booster in colon capsule regimens significantly improves completion rates and polyp detection
Serhiy Semenov, Mohd Syafiq Ismail, Fintan O'Hara, Sandeep Sihag, Barbara Ryan, Anthony O'Connor, Sarah O'Donnell, Deirdre McNamara
Serhiy Semenov, Mohd Syafiq Ismail, Fintan O'Hara, Sandeep Sihag, Barbara Ryan, Anthony O'Connor, Sarah O'Donnell, Deirdre McNamara, Gastroenterology Department, Tallaght University Hospital, Dublin D 24, Ireland
Serhiy Semenov, Mohd Syafiq Ismail, Fintan O'Hara, Sandeep Sihag, Deirdre McNamara, Trinity Academic Gastroenterology Group, Trinity College Dublin, Dublin D 2, Ireland
Author contributions: Semenov S is the primary author of this study and is responsible for writing, editing and submitting the manuscript; Semenov S and McNamara D designed the research study; Semenov S, Ismail MS, Sihag S and O'Hara F assisted in data collection; O'Connor A, O'Donnell S, Ryan B and McNamara D played vital advisory roles in facilitating ethical approval, editing the manuscript and data collection.
Institutional review board statement: This study was approved and registered on the November 15, 2019, as a service evaluation project by the process improvement department which is part of the quality safety and risk management directorate of Tallaght University Hospital, Tallaght, Dublin 24, Ireland.
Informed consent statement: This form is not applicable as this study has been registered as a service evaluation project by the process improvement department which is part of the quality safety and risk management directorate in our hospital.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: Consent for data sharing was not obtained as the presented data is anonymized as per registration agreement with the quality safety and risk management directorate of our hospital.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Serhiy Semenov, MRCP, Doctor, Gastroenterology Department, Tallaght University Hospital, Tallaght Dublin 24, Dublin D 24, Ireland. semenovs@tcd.ie
Received: March 1, 2021
Peer-review started: March 1, 2021
First decision: April 18, 2021
Revised: May 2, 2021
Accepted: September 3, 2021
Article in press: September 3, 2021
Published online: November 5, 2021
Processing time: 245 Days and 20.2 Hours
Core Tip

Core Tip: This is the largest prospective study to date, assessing the impact of castor oil and its novel use as a colon capsule endoscopy (CCE) booster in an unselected cohort. Our study shows that adding castor oil to a simple split-dose CCE bowel preparation regime has a significant impact on capsule excretion rates and polyp detection.