Update on management of Barrett's esophagus

doi:10.4292/wjgpt.v7.i2.227

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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World J Gastrointest Pharmacol Ther. May 6, 2016; 7(2): 227-234
Published online May 6, 2016. doi: 10.4292/wjgpt.v7.i2.227

Update on management of Barrett's esophagus

Fernando Macías-García, J Enrique Domínguez-Muñoz

Fernando Macías-García, J Enrique Domínguez-Muñoz, Department of Gastroenterology and Hepatology, University Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain

Fernando Macías-García, J Enrique Domínguez-Muñoz, Foundation for Research in Digestive Diseases (FIENAD), University Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain

Author contributions: Macías-García F wrote the paper; Domínguez-Muñoz JE supervision and final approval of the article.

Conflict-of-interest statement: Authors declare no conflict of interests for this article.

Correspondence to: Fernando Macías-García, MD, Department of Gastroenterology and Hepatology, University Hospital of Santiago de Compostela, Choupana s/n, 15706 Santiago de Compostela, Spain. fmacgar@yahoo.es

Telephone: +34-98-1951364 Fax: +34-98-1951365

Received: April 25, 2015
Peer-review started: April 27, 2015
First decision: September 8, 2015
Revised: December 15, 2015
Accepted: February 14, 2016
Article in press: February 16, 2016
Published online: May 6, 2016
Processing time: 361 Days and 5.2 Hours

Abstract

Barrett's esophagus (BE) is a common condition that develops as a consequence of gastroesophageal reflux disease. The significance of Barrett's metaplasia is that predisposes to cancer development. This article provides a current evidence-based review for the management of BE and related early neoplasia. Controversial issues that impact the management of patients with BE, including definition, screening, clinical aspects, diagnosis, surveillance, and management of dysplasia and early cancer have been assessed.

Keywords: Barrett’s esophagus; Barrett metaplasia; Esophageal adenocarcinoma; Gastroesophageal reflux disease; Radiofrequency ablation

Core tip: Barrett’s esophagus (BE) is a common condition that predisposes to cancer development. This article provides a current evidence-based review for controversial issues that impact the management of patients with BE, including clinical aspects, diagnosis, surveillance, and management of dysplasia and early cancer.