Wishahi M. Gut microbiotas attributed to disorders and diseases of the gastrointestinal tract, colorectal cancer, bladder cancer: Geographical factors, inflammation, metabolic toxic. World J Gastrointest Pharmacol Ther 2026; 17(1): 115573 [DOI: 10.4292/wjgpt.v17.i1.115573]
Corresponding Author of This Article
Mohamed Wishahi, Department of Urology, Theodor Bilharz Research Institute, Embaba, Giza, Cairo 12411, Egypt. moh.weshahy@gmail.com
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Oncology
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Editorial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mar 5, 2026 (publication date) through Feb 11, 2026
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Publication Name
World Journal of Gastrointestinal Pharmacology and Therapeutics
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2150-5349
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Wishahi M. Gut microbiotas attributed to disorders and diseases of the gastrointestinal tract, colorectal cancer, bladder cancer: Geographical factors, inflammation, metabolic toxic. World J Gastrointest Pharmacol Ther 2026; 17(1): 115573 [DOI: 10.4292/wjgpt.v17.i1.115573]
World J Gastrointest Pharmacol Ther. Mar 5, 2026; 17(1): 115573 Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.115573
Gut microbiotas attributed to disorders and diseases of the gastrointestinal tract, colorectal cancer, bladder cancer: Geographical factors, inflammation, metabolic toxic
Mohamed Wishahi
Mohamed Wishahi, Department of Urology, Theodor Bilharz Research Institute, Cairo 12411, Egypt
Author contributions: Wishahi M contributed to conception and design, collection and assembly of data, data analysis and interpretation, manuscript writing, revision, and final approval of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohamed Wishahi, Department of Urology, Theodor Bilharz Research Institute, Embaba, Giza, Cairo 12411, Egypt. moh.weshahy@gmail.com
Received: October 20, 2025 Revised: November 19, 2025 Accepted: January 19, 2026 Published online: March 5, 2026 Processing time: 114 Days and 7 Hours
Abstract
Recently, there were several publications that attributed gut microbiota (GM) to various gastrointestinal tract functional disorders and diseases, including inflammatory bowel diseases, colon cancer, pancreatic cancer, and diverticulosis. GM is attributed to the initiation of urinary tract diseases and bladder carcinoma (BCa). The concern is whether GM is dysbiotic or protective. We explored the studies on GM contribution to colorectal cancer and BCa. Selected studies from different geographical regions on tissue samples or faecal samples from patients with colorectal cancer and controls. The results showed diverging results of microbiota abundance, genus, class, and phylum. These data indicated that other factors of environmental, diet, ethnic, and personal factors are contributors to GM in the initiation of inflammation and tumors. GM are not inhabitants in the urinary tract; it is postulated that GM attributes to BCa via the circulating metabolic toxins in the initiation of tumorigenesis and BCa.
Core Tip: Several studies on gut microbiota (GM) and its attribute to colorectal cancer and bladder carcinoma (BCa) from different geographical regions on tissue or faecal samples from patients with colorectal cancer and controls have shown diverging non-unified results of microbiota abundance, genus, class, and phylum. These data indicated that the impact of environmental factors, diet, and ethnic factors, in addition to GM, contributes to carcinoma. GM are not inhabitants in the urinary tract; the postulation that GM attributes to BCa assumes that the circulating metabolic toxins are tumorigenic and would initiate BCa.
