Murugan N, Figueroa Hernandez Y, Amin N, Dahip M, Daglilar E, Chela HK. Uncommon metastatic pattern of renal cell carcinoma (simultaneous metastasis to the small intestine and skeletal muscle): A case report. World J Gastrointest Pharmacol Ther 2025; 16(3): 108266 [DOI: 10.4292/wjgpt.v16.i3.108266]
Corresponding Author of This Article
Harleen Kaur Chela, Assistant Professor, Department of Gastroenterology and Hepatology, Charleston Area Medical Center, West Virginia University School of Medicine, 64 Medical Center Drive, Charleston, WV 25304, United States. harleen.chela@camc.org
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Naveena Murugan, Department of Internal Medicine, West Virginia University School of Medicine, Charleston, WV 25304, United States
Yodsui Figueroa Hernandez, Department of Anatomy and Laboratory Medicine, West Virginia University-Pathology, Morgantown, WV 26506, United States
Nisar Amin, Department of Internal Medicine, Charleston Area Medical Center, Charleston, WV 25304, United States
Michael Dahip, Department of Gastroenterology and Hepatology, Dignity Health Medical Group, Chandler, AZ 85224, United States
Ebubekir Daglilar, Department of Gastroenterology and Hepatology, West Virginia University-Charleston Division, Charleston, WV 25304, United States
Harleen Kaur Chela, Department of Gastroenterology and Hepatology, Charleston Area Medical Center, West Virginia University School of Medicine, Charleston, WV 25304, United States
Author contributions: All authors have contributed to the formulation of the manuscript, read and approved the final version of the manuscript to be published.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: There is no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Harleen Kaur Chela, Assistant Professor, Department of Gastroenterology and Hepatology, Charleston Area Medical Center, West Virginia University School of Medicine, 64 Medical Center Drive, Charleston, WV 25304, United States. harleen.chela@camc.org
Received: April 9, 2025 Revised: April 30, 2025 Accepted: June 23, 2025 Published online: September 5, 2025 Processing time: 148 Days and 2.5 Hours
Abstract
BACKGROUND
Metastasis of renal cell carcinoma (RCC) to the skeletal muscle and small bowel is an exceedingly rare occurrence. Both of these sites are unusual sites for RCC to metastasize to and to occur simultaneously is even less common.
CASE SUMMARY
A 58-year-old male with known history of RCC presented with a recurrence that was diagnosed through imaging and biopsies. Mucosa abnormalities of small bowel noted during endoscopy were biopsied as well as lesion in the psoas muscle that was noted.
CONCLUSION
This case report emphasizes that RCC can not only recur but can do so even decades later and present as metastatic foci at atypical sites.
Core Tip: Renal cell carcinoma is a malignant tumor that can recur despite treatment similar to other malignancies. The recurrence can present itself as a metastatic process. The involvement of two sites simultaneously as metastatic recurrence is quite uncommon, more so for that to be the small intestine and the skeletal muscle (psoas).
