©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. May 15, 2016; 7(2): 218-222
Published online May 15, 2016. doi: 10.4291/wjgp.v7.i2.218
Published online May 15, 2016. doi: 10.4291/wjgp.v7.i2.218
Clinical impacts of mesothelin expression in gastrointestinal carcinomas
Takahiro Einama, Futoshi Kawamata, Hirofumi Kamachi, Shigenori Homma, Fumihiko Matsuzawa, Tatsuzo Mizukami, Yuji Konishi, Munenori Tahara, Toshiya Kamiyama, Akinobu Taketomi, Department of General Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan
Hiroshi Nishihara, Department of Translational Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan
Okio Hino, Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo 113-8421, Japan
Satoru Todo, Research institute of St. Mary’s Hospital, Kurume 830-8558, Japan
Author contributions: All authors equally contributed to this paper regarding its conception, literature review, editing and approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest.
Correspondence to: Takahiro Einama, MD, PhD, Department of General Surgery, Hokkaido University Graduate School of Medicine, Kita-Ku, Kita 14, Nishi 7, Sapporo, Hokkaido 060-8638, Japan. titiuehahaue@hotmail.com
Telephone: +81-11-7065927 Fax: +81-11-7177515
Received: September 29, 2015
Peer-review started: October 2, 2015
First decision: November 4, 2015
Revised: December 8, 2015
Accepted: January 27, 2016
Article in press: January 29, 2016
Published online: May 15, 2016
Processing time: 226 Days and 18.5 Hours
Peer-review started: October 2, 2015
First decision: November 4, 2015
Revised: December 8, 2015
Accepted: January 27, 2016
Article in press: January 29, 2016
Published online: May 15, 2016
Processing time: 226 Days and 18.5 Hours
Core Tip
Core tip: Mesothelin is a 40-kDa cell surface glycoprotein expressed on normal mesothelial cells lining the pleura, pericardium, and peritoneum. Moreover, mesothelin has been shown to be overexpressed in several cancer types. Recent studies have suggested that the overexpression of mesothelin increases cell proliferation and migration. Furthermore, the expression of mesothelin was related to an unfavourable patient outcome in several human cancers. The limited mesothelin expression in normal tissues and high expression in many cancers makes it an attractive candidate for cancer therapy.