Nangia-Makker P, Yu Y, Majumdar AP. Role of cancer stem cells in age-related rise in colorectal cancer. World J Gastrointest Pathophysiol 2015; 6(4): 86-89 [PMID: 26600965 DOI: 10.4291/wjgp.v6.i4.86]
Corresponding Author of This Article
Pratima Nangia-Makker, PhD, Veterans Affairs Medical Center, Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University-School of Medicine, Research Service, 4646 John R, Room-B4238, Detroit, MI 48201, United States. makkerp@karmanos.org
Research Domain of This Article
Pathology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Pratima Nangia-Makker, Yingjie Yu, Adhip PN Majumdar, Veterans Affairs Medical Center, Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University-School of Medicine, Research Service, Detroit, MI 48201, United States
Author contributions: Nangia-Makker P designed and wrote the editorial; Yu Y designed and performed the experiments; Majumdar APN was invited to contribute to the editorial, conceptualized and wrote the editorial, and contributed to research design.
Supported by The National Institutes of Health AG014343, 1R21CA175916-01; the Department of Veterans Affairs (I101BX001927); and the Metropolitan Detroit Research and Education Foundation (to Adhip PN Majumdar).
Conflict-of-interest statement: The authors have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Pratima Nangia-Makker, PhD, Veterans Affairs Medical Center, Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University-School of Medicine, Research Service, 4646 John R, Room-B4238, Detroit, MI 48201, United States. makkerp@karmanos.org
Telephone: +1-313-5754460 Fax: +1-313-5761112
Received: June 2, 2015 Peer-review started: June 4, 2015 First decision: July 6, 2015 Revised: September 2, 2015 Accepted: September 16, 2015 Article in press: September 18, 2015 Published online: November 15, 2015 Processing time: 167 Days and 20.3 Hours
Core Tip
Core tip: Sporadic colorectal cancer (CRC), an age-related disease, occurs in 80%-85% of patients with CRC. The changes that occur at the cellular and molecular levels during ageing leading to a rise in CRC are poorly understood. We have postulated a role for cancer stem/stem-like cells that are shown to possess self-renewing, pluripotent properties. These cells, which reside at the bottom of the colonic crypt, are thought to regulate the processes of carcinogenesis. In this editorial, we have briefly described the recent work on the evolution of cancer stem cells in gastro-intestinal tract with particular reference to the colon, and how they are involved in the development and progression of CRC, the incidence of which increases with advancing age.
