©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Aug 15, 2015; 6(3): 73-78
Published online Aug 15, 2015. doi: 10.4291/wjgp.v6.i3.73
Published online Aug 15, 2015. doi: 10.4291/wjgp.v6.i3.73
Designer probiotics: Development and applications in gastrointestinal health
Roy D Sleator, Department of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland
Author contributions: Sleator RD conceived of the idea and wrote the paper.
Conflict-of-interest statement: There are no conflicts of interest.
Correspondence to: Roy D Sleator, Senior Lecturer and PI, Department of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland. roy.sleator@cit.ie
Telephone: +353-21-4335405
Received: March 11, 2015
Peer-review started: March 12, 2015
First decision: April 13, 2015
Revised: April 23, 2015
Accepted: July 11, 2015
Article in press: July 14, 2015
Published online: August 15, 2015
Processing time: 159 Days and 13.5 Hours
Peer-review started: March 12, 2015
First decision: April 13, 2015
Revised: April 23, 2015
Accepted: July 11, 2015
Article in press: July 14, 2015
Published online: August 15, 2015
Processing time: 159 Days and 13.5 Hours
Core Tip
Core tip: Genetically engineered probiotic bacteria, with improved in vivo stress survival and persistence, have the potential to enhance, and in some instances replace, conventional prophylactic and therapeutic measures. This is particularly relevant in the developing world, where chronic and acute infections, and their associated sequelae impose a significant clinical and economic burden.