Genetics of acute and chronic pancreatitis: An update

doi:10.4291/wjgp.v5.i4.427

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Nov 15, 2014; 5(4): 427-437
Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.427

Genetics of acute and chronic pancreatitis: An update

VV Ravi Kanth, D Nageshwar Reddy

VV Ravi Kanth, Asian Healthcare Foundation, Somajiguda, Hyderabad 500082, Andhra Pradesh, India

D Nageshwar Reddy, Asian Institute of Gastroenterology and Asian Healthcare Foundation, Somajiguda, Hyderabad 500082, India

Author contributions: Ravi Kanth VV wrote the initial draft; Nageshwar Reddy D reviewed the manuscript and approved the final draft.

Correspondence to: Dr. D Nageshwar Reddy, Asian Institute of Gastroenterology and Asian Healthcare Foundation, 6-3-661, Somajiguda, Hyderabad 500082, India. aigindia@yahoo.co.in

Telephone: +91-40-23378888 Fax: +91-40-23324255

Received: December 27, 2013
Revised: October 1, 2014
Accepted: October 14, 2014
Published online: November 15, 2014
Processing time: 326 Days and 21.9 Hours

Core Tip

Core tip: Pancreatitis is a progressive inflammatory disease. Though the pancreas has adequate protection against environmental and metabolic stress, if the magnitude of this stress exceeds the threshold which the organ can handle, it leads to pathologic effects. Although genetic variables have been identified that affect the function of pancreas, namely polymorphisms in serine protease inhibitor kazal type 1 (SPINK1), polymorphisms in cationic trypsinogen (PRSS1) and Chymotrypsinogen C (CTRC) genes in the acinar cells and cystic fibrosis trans-membrane conductance regulator (CFTR), calcium sensing receptor (CASR genes) in the ductal cells leading to pancreatitis, off late many genetic factors outside of the “intra-pancreatic trypsin regulatory mechanism” have been identified for their role in pancreatitis. This review is an update on the genetic aspects of acute and chronic pancreatitis.