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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Sep 22, 2025; 16(3): 108058
Published online Sep 22, 2025. doi: 10.4291/wjgp.v16.i3.108058
Published online Sep 22, 2025. doi: 10.4291/wjgp.v16.i3.108058
Dynamics of tissue and fecal microbiota in active Crohn’s disease and their ability to predict disease state
Amit K Dutta, AJ Joseph, Department of Gastroenterology, Christian Medical College, Vellore 632004, Tamil Nadu, India
Dilip Abraham, Blossom Benny, Karthikeyan Govindan, Zayina Zondervenni, Wellcome Trust Research Laboratory, Christian Medical College Vellore, Vellore 632004, Tamil Nadu, India
Ira Praharaj, Regional Medical Research Centre, Indian Council of Medical Research Regional Medical Research Centre Bhubaneswar, Bhubaneshwar 751023, Odisha, India
Author contributions: Dutta AK, Abraham D, Praharaj I, Benny B, Govindan K, Zondervenni Z, and Joseph AJ carried out the research, collection and interpretation of the data; Dutta AK carried out the planning; Dutta AK and Abraham D drafted the manuscript; Praharaj I, Benny B, Govindan K, Zondervenni Z, and Joseph AJ made important revisions to the manuscript; and all authors have read and approved the final manuscript.
Supported by the Science and Engineering Research Board, No. EMR/2016/007033.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Christian Medical College Vellore, approval No. 10698.
Informed consent statement: Written informed consent was obtained from all the participants before enrolment into this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The microbiome sequencing data from this study will be made available for research purpose on request to the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Amit K Dutta, Academic Fellow, Professor, Department of Gastroen
Received: April 8, 2025
Revised: April 18, 2025
Accepted: June 11, 2025
Published online: September 22, 2025
Processing time: 168 Days and 16.6 Hours
Revised: April 18, 2025
Accepted: June 11, 2025
Published online: September 22, 2025
Processing time: 168 Days and 16.6 Hours
Core Tip
Core Tip: Gut microbiota is emerging as a key player in the pathogenesis of Crohn’s disease (CD). The mucosal gut micro