Editorial
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Nov 22, 2021; 12(6): 106-114
Published online Nov 22, 2021. doi: 10.4291/wjgp.v12.i6.106
Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis
Christos Doudakmanis, Konstantinos Bouliaris, Christina Kolla, Matthaios Efthimiou, Georgios D Koukoulis
Christos Doudakmanis, Konstantinos Bouliaris, Christina Kolla, Matthaios Efthimiou, Georgios D Koukoulis, Department of General Surgery, General Hospital of Larissa, Larisa 41221, Greece
Author contributions: Koukoulis GD and Doudakmanis C were responsible for conception and design of the study and acquisition of the data; Bouliaris K and Doudakmanis C were responsible for analysis and interpretation of the data; Doudakmanis C, Bouliaris K, Koukoulis GD, Kolla C, and Efthimiou M were responsible for drafting of the article; Efthimiou M was responsible for critical revision of the manuscript for important intellectual content; all authors read and approved the final version of the manuscript.
Conflict-of-interest statement: Christos Doudakmanis, Konstantinos Bouliaris, Christina Kolla, Matthaios Efthimiou, and Georgios D Koukoulis declare that they have nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Georgios D Koukoulis, MD, MSc, PhD, Adjunct Professor, Doctor, Surgeon, Department of General Surgery, General Hospital of Larissa, Tsakalof 1, Larisa 41221, Greece. georgios.koukoulis@gmail.com
Received: March 16, 2021
Peer-review started: March 16, 2021
First decision: May 6, 2021
Revised: May 14, 2021
Accepted: September 14, 2021
Article in press: September 14, 2021
Published online: November 22, 2021
Processing time: 244 Days and 10.1 Hours
Core Tip

Core Tip: Increased intestinal permeability can potentially induce intestinal flora dysbiosis. Bacterial translocation, attributed to intestinal barrier impairment, may lead to systematic infection in the postoperative period. The definitive correlation between translocation and postoperative sepsis is yet to be proven, but the latter is an emerging issue for patients undergoing major gastrointestinal surgeries.