Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification
Mireia Lopez-Siles, Xavier Aldeguer, Miriam Sabat-Mir, Mariona Serra-Pagès, Sylvia H Duncan, Harry J Flint, L Jesús Garcia-Gil, Margarita Martinez-Medina
Mireia Lopez-Siles, L Jesús Garcia-Gil, Margarita Martinez-Medina, Laboratory of Molecular Microbiology, Biology Department, Universitat de Girona, Girona 17003, Spain
Xavier Aldeguer, Department of Gastroenterology, Hospital Universitari Dr. Josep Trueta, Girona 17007, Spain
Miriam Sabat-Mir, Department of Gastroenterology, Hospital Santa Caterina, Salt 17190, Spain
Mariona Serra-Pagès, GoodGut SL, Girona 17003, Spain
Sylvia H Duncan, Harry J Flint, Microbiology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
Author contributions: Martinez-Medina M and Garcia-Gil LJ contributed to conception and design of the study; López-Siles M, Aldeguer X, Sabat-Mir M and Serra-Pagès M were actively involved in data acquisition; López-Siles M and Martinez-Medina M were involved in data analysis and interpretation; López-Siles M, Martinez-Medina M, Duncan S and Flint H drafted the article; all authors revised the article for important intellectual content and approved the final version of the manuscript.
Supported by the Spanish Ministry of Education and Science, No. SAF2010-15896, No. SAF2013-43284-P and No. SAF2017-82261-P.
Institutional review board statement: This work was reviewed and approved by the Ethics Committee of Clinical Research of the Hospital Universitari Dr. Josep Trueta (Girona, Spain) and the Institut d’Assistència Sanitària of Girona (Salt, Spain) on 24th February 2009 and 21st April 2009, respectively.
Informed consent statement: Informed consent from the subjects was obtained before enrolment.
Conflict-of-interest statement: Aldeguer X is a consultant from AbbVie and has received honoraria for lectures, including services on speakers’ bureaus, from AbbVie, MSD, Shire and Takeda. Aldeguer X, Serra-Pagès, M and Garcia-Gil J own shares in GoodGut S.L. López-Siles M, Garcia-Gil J, Aldeguer X and Martinez-Medina M own patent WO2017025617A1 concerning a Method for the detection, follow up and/or classification of intestinal diseases. The other authors have nothing to disclose.
Data sharing statement: Datasets available from the corresponding author at marga.martinez@udg.edu. Consent was not obtained from participants for data sharing, but the presented data are anonymized, and the risk of identification is low. No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE-Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Margarita Martinez-Medina, PhD, Associate Professor, Laboratory of Molecular Microbiology, Biology Department, Universitat de Girona, Carrer de Maria Aurèlia Capmany, 40, Girona 17003, Spain.
marga.martinez@udg.edu
Received: December 30, 2019
Peer-review started: December 30, 2019
First decision: January 13, 2020
Revised: February 27, 2020
Accepted: March 30, 2020
Article in press: March 30, 2020
Published online: May 12, 2020
Processing time: 133 Days and 12.3 Hours
