Observational Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Feb 15, 2017; 8(1): 3-10
Published online Feb 15, 2017. doi: 10.4291/wjgp.v8.i1.3
Polyp detection rate and pathological features in patients undergoing a comprehensive colonoscopy screening
Hamid Asadzadeh Aghdaei, Ehsan Nazemalhosseini Mojarad, Sara Ashtari, Mohmad Amin Pourhoseingholi, Vahid Chaleshi, Fakhrosadat Anaraki, Mehrdad Haghazali, Mohammad Reza Zali
Hamid Asadzadeh Aghdaei, Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 19835-178, Iran
Ehsan Nazemalhosseini Mojarad, Sara Ashtari, Mohmad Amin Pourhoseingholi, Vahid Chaleshi, Mehrdad Haghazali, Mohammad Reza Zali, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 19835-178, Iran
Fakhrosadat Anaraki, Colorectal Division of Department of Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran 19835-178, Iran
Author contributions: Asadzadeh Aghdaei H, Haghazali M and Zali MR performed all colonoscopies; Asadzadeh Aghdaei H drafted the initial manuscript; Nazemalhosseini Mojarad E and Anaraki F were the guarantors and designed the study; Chaleshi V gathered the data; Ashtari S participated in the acquisition, analysis, and interpretation of the data, and wrote and revised the last version of manuscript; Pourhoseingholi MA as PhD of biostatistics revised the article for statistical materials and methods.
Supported by Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Institutional review board statement: The study was reviewed and approved by the Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sara Ashtari, MSc of Epidemiology in Research Institute of Gastroenterology and Liver Diseases, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tabnak St, Yaman Ave, Velenjak, Tehran 19835-178, Iran. sara_ashtari@yahoo.com
Telephone: +98-21-22432515 Fax: +98-21-22432517
Received: September 13, 2016
Peer-review started: September 14, 2016
First decision: October 21, 2016
Revised: November 23, 2016
Accepted: December 7, 2016
Article in press: December 9, 2016
Published online: February 15, 2017
Processing time: 149 Days and 19.9 Hours
Abstract
AIM

To identify the prevalence, and clinical and pathologic characteristic of colonic polyps among Iranian patients undergoing a comprehensive colonoscopy, and determine the polyp detection rate (PDR) and adenoma detection rate (ADR).

METHODS

In this cross-sectional study, demographics and epidemiologic characteristics of 531 persons who underwent colonoscopies between 2014 and 2015 at Mehrad gastrointestinal clinic were determined. Demographics, indication for colonoscopy, colonoscopy findings, number of polyps, and histopathological characteristics of the polyps were examined for each person.

RESULTS

Our sample included 295 (55.6%) women and 236 (44.4%) men, with a mean age of 50.25 ± 14.89 years. Overall PDR was 23.5% (125/531). ADR and colorectal cancer detection rate in this study were 12.8% and 1.5%, respectively. Polyps were detected more significantly frequently in men than in women (52.8% vs 47.2%, P < 0.05). Polyps can be seen in most patients after the age of 50. The average age of patients with cancer was significantly higher than that of patients with polyps (61.3 years vs 56.4 years, P < 0.05). The majority of the polyps were adenomatous. More than 50% of the polyps were found in the rectosigmoid part of the colon.

CONCLUSION

The prevalence of polyps and adenomas in this study is less than that reported in the Western populations. In our patients, distal colon is more susceptible to developing polyps and cancer than proximal colon.

Keywords: Adenoma detection; Polyp detection; Iran; Colonoscopy; Screening

Core tip: One of the major reasons for colonoscopy is detection of colon polyps, such as adenomas. Early diagnosis and endoscopic removal of adenomatous polyps is one of the main objectives for screening and prevention of colorectal cancer (CRC). Given that, only few studies are available in the national literature regarding the assessment of colorectal polyps, but none has explicitly noted the rate of polyp detection. Nevertheless, our study provides comprehensive information about clinical and epidemiological features of colorectal polyps. Therefore, the results of this study can provide a good infrastructure for the next preventive program and have clinical implications for CRC screening.