Antonini F, Pezzilli R, Angelelli L, Macarri G. Pancreatic disorders in inflammatory bowel disease. World J Gastrointest Pathophysiol 2016; 7(3): 276-282 [PMID: 27574565 DOI: 10.4291/wjgp.v7.i3.276]
Corresponding Author of This Article
Filippo Antonini, MD, Department of Gastroenterology, A.Murri Hospital, Polytechnic University of Marche, Ospedale “A.Murri”, 63900 Fermo, Italy. filippore@yahoo.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Filippo Antonini, Giampiero Macarri, Department of Gastroenterology, A.Murri Hospital, Polytechnic University of Marche, 63900 Fermo, Italy
Raffaele Pezzilli, Department of Digestive Diseases and Internal Medicine, Sant’Orsola-Malpighi Hospital, 40138 Bologna, Italy
Lucia Angelelli, Medical Oncology, Mazzoni Hospital, 63100 Ascoli Piceno, Italy
Author contributions: Antonini F designed the research; Antonini F and Pezzilli R did the data collection and analyzed the data; Antonini F, Pezzilli R and Angelelli L wrote the paper; Macarri G revised the paper and granted the final approval.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Filippo Antonini, MD, Department of Gastroenterology, A.Murri Hospital, Polytechnic University of Marche, Ospedale “A.Murri”, 63900 Fermo, Italy. filippore@yahoo.it
Telephone: +39-0734-6252249 Fax: +39-0734-6252252
Received: May 24, 2016 Peer-review started: May 25, 2016 First decision: June 17, 2016 Revised: July 8, 2016 Accepted: July 20, 2016 Article in press: July 22, 2016 Published online: August 15, 2016 Processing time: 78 Days and 13.7 Hours
Abstract
An increased incidence of pancreatic disorders either acute pancreatitis or chronic pancreatitis has been recorded in patients with inflammatory bowel disease (IBD) compared to the general population. Although most of the pancreatitis in patients with IBD seem to be related to biliary lithiasis or drug induced, in some cases pancreatitis were defined as idiopathic, suggesting a direct pancreatic damage in IBD. Pancreatitis and IBD may have similar presentation therefore a pancreatic disease could not be recognized in patients with Crohn’s disease and ulcerative colitis. This review will discuss the most common pancreatic diseases seen in patients with IBD.
Core tip: Pancreatic disorders are not uncommon in patients with inflammatory bowel disease (IBD). The most frequent manifestation is acute pancreatitis (AP). Causes of AP are mainly a concomitant biliary lithiasis or drugs used in the treatment of IBD. However for some IBD-related pancreatitis, idiopathic by definition, where no relationship with lithiasis or drugs can be recognized, a direct pancreatic damage would be hypothesized.
