Xu GY, Li Y, Zhang WZ. Gastric mammalian target of rapamycin signaling, hormone production and energy metabolism. World J Gastrointest Pathophysiol 2011; 2(6): 109-113 [PMID: 22180845 DOI: 10.4291/wjgp.v2.i6.109]
Corresponding Author of This Article
Wei-Zhen Zhang, Professor, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China. weizhenzhang@bjmu.edu.cn
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World J Gastrointest Pathophysiol. Dec 15, 2011; 2(6): 109-113 Published online Dec 15, 2011. doi: 10.4291/wjgp.v2.i6.109
Gastric mammalian target of rapamycin signaling, hormone production and energy metabolism
Ge-Yang Xu, Yin Li, Wei-Zhen Zhang
Ge-Yang Xu, Yin Li, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
Wei-Zhen Zhang, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
Wei-Zhen Zhang, Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109-0346, United States
Author contributions: Xu GY drafted the manuscript; Li Y helped to edit the paper; Zhang WZ proposed, edited and revised the manuscript.
Supported by Grants from the National Natural Science Foundation of China, No. 30971434, 30871194, 30971085 and 81030012; Program for New Century Excellent Talents in University, Beijing Natural Science Foundation, No. 7112080
Correspondence to: Wei-Zhen Zhang, Professor, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China. weizhenzhang@bjmu.edu.cn
Telephone: +86-10-82802183 Fax: +86-10-82802183
Received: May 28, 2011 Revised: October 7, 2011 Accepted: October 14, 2011 Published online: December 15, 2011
Abstract
The obesity epidemic imposes a significant health burden on human beings. Current understanding of the mechanisms underlying the development of obesity is incomplete and contemporary treatment is often ineffective. Gastrointestinal hormones are important regulators of food intake and energy metabolism. Previous studies indicate that the mammalian target of rapamycin signaling pathway in the gastric mucosa is crucially involved in fuel sensing in the gastrointestinal tract and plays a critical role in the coordination of nutrient availability and ingestive behavior via the production of gastric hormones. As an important component of the brain-gut axis regulating food intake and energy homeostasis, energy sensing in the gastrointestinal tract may provide a novel insight into our understanding of the precise coordination between the organism and cellular energy state.
