CO2BOLD assessment of moyamoya syndrome: Validation with single photon emission computed tomography and positron emission tomography imaging

Table 1 Essential demographic and clinical data of the included patients

No	Age	Gender	Diagnosis	Etiology	Treatment	PET	SPECT	BOLD
1	53	F	Bilateral moyamoya	Unknown	Bypass	0	1	1
2	41	F	Bilateral moyamoya	Unknown	Bypass	1	2	3
3	26	F	Left moyamoya	Unknown	Bypass	1	1	1
4	15	F	Right moyamoya	Unknown	Conservative	0	1	1
5	42	F	Bilateral moyamoya	Unknown	Bilateral bypass	0	1	1
6	39	F	Bilateral moyamoya	Unknown	Bypass	2	0	2
7	51	M	Right moyamoya	Dissection	Bypass	0	1	1
8	42	F	Right moyamoya	Unknown	Bypass	0	2	2
9	46	M	Bilateral moyamoya	Unknown	Conservative	0	1	1
10	58	F	Bilateral moyamoya	Stenosis	Bypass	0	1	1
Mean age	41.3				Total	4	11	14

PET: Positron emission tomography; SPECT: Single photon emission computed tomography; F: Female; M: Male.

Table 2 Concordance between CO₂BOLD and positron emission tomography/single photon emission computed tomography

	PET/SPECT pathologic	PET/SPECT normal
CO2BOLD pathologic	6	4	PPV 60%
	TP 43%	FP 29%
CO2BOLD normal	1	3	NPV 75%
	FN 7%	TN 21%
	SENS 86%	SPEC 43%	ACC 64%

TP: True positive; TN: True negative; FP: False positive; FN: False negative; SENS: Sensitivity; SPEC: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; ACC: Accuracy; PET: Positron emission tomography; SPECT: Single photon emission computed tomography.