Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer

doi:10.4329/wjr.v16.i7.256

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Jul 28, 2024 (publication date) through Sep 19, 2024

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World Journal of Radiology

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1949-8470

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Radiol. Jul 28, 2024; 16(7): 256-264
Published online Jul 28, 2024. doi: 10.4329/wjr.v16.i7.256

Table 1 Patient characteristics, n (%)

Characteristics (n = 259)
Age (years)
Median (range)	71 (54-87)
Karnofsky performance status
100	232 (89.5)
90	24 (9.3)
80	1 (0.4)
60	2 (0.8)
Follow-up time (months)
Median (range)	31 (14-40)
Initial prostate-specific antigen (ng/mL)
Median (range)	8.23 (0.62-1354)
T category
1b	1 (0.4)
1c	39 (15.1)
2a	99 (38.2)
2b	34 (13.0)
2c	57 (22.0)
3a	19 (7.3)
3b	8 (3.1)
4	2 (0.8)
Gleason score
6	39 (15.1)
7	119 (45.9)
8	65 (25.1)
9	35 (13.5)
10	1 (0.4)
Diabetes mellitus
Yes	29 (11.2)
No	230 (88.8)
Anticoagulation therapy
Yes	38 (14.7)
No	221 (85.3)
Androgen deprivation therapy
Yes	234 (90.3)
No	25 (9.7)
Planning target volume (cc)
Median (range)	80.71 (43.24-202.60)

Table 2 The correlation between dose–volume parameter of rectum and rectal bleeding, mean ± SD

	Grade 0	Grade 1/2	P value
D 6cc	25.40 ± 7.56 Gy (RBE)	30.93 ± 6.75 Gy (RBE)	0.001^a
D 2cc	44.54 ± 2.88 Gy (RBE)	45.93 ± 1.71 Gy (RBE)	0.005^a
D 0.2cc	49.73 ± 0.98 Gy (RBE)	49.80 ± 0.34 Gy (RBE)	0.592
V 10 Gy (RBE)	10.45 ± 2.72 cc	11.89 ± 2.79 cc	0.010^a
V 20 Gy (RBE)	7.46 ± 2.05 cc	8.90 ± 2.29 cc	0.002^a
V 30 Gy (RBE)	5.32 ± 1.57 cc	6.56 ± 1.78 cc	0.001^a
V 40 Gy (RBE)	3.34 ± 1.05 cc	4.15 ± 1.12 cc	0.001^a
V 50 Gy (RBE)	0.18 ± 0.10 cc	0.17 ± 0.12 cc	0.590

^aP < 0.05.

RBE: Relative biological effectiveness.

Table 3 The comparison of ratio of rectal bleeding before and after cutoff values of dose-volume parameters calculated by using receiver operating characteristic curves

	Comparison	Number of patients	Ratio of grade 2 rectal bleeding (%)	P value
D 6cc	≥ 34.34 Gy (RBE)	54	5.3	0.42
	< 34.34 Gy (RBE)	202	3.0
D 2cc	≥ 46.46 Gy (RBE)	65	7.7	0.047^a
	< 46.46 Gy (RBE)	194	2.1
V 10 Gy (RBE)	≥ 9.85 cc	136	5.9	0.038^a
	< 9.85 cc	123	0.8
V 20 Gy (RBE)	≥ 7.00 cc	139	5.8	0.040^a
	< 7.00 cc	120	0.8
V 30 Gy (RBE)	≥ 6.91 cc	48	6.0	0.374
	< 6.91 cc	211	6.3
V 40 Gy (RBE)	≥ 4.26 cc	59	1.7	0.689
	< 4.26 cc	200	4.0

^aP < 0.05.

RBE: Relative biological effectiveness.

Citation: Ono T, Sato H, Miyasaka Y, Hagiwara Y, Yano N, Akamatsu H, Harada M, Ichikawa M. Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer. World J Radiol 2024; 16(7): 256-264
URL: https://www.wjgnet.com/1949-8470/full/v16/i7/256.htm
DOI: https://dx.doi.org/10.4329/wjr.v16.i7.256