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©The Author(s) 2024.
World J Radiol. Jul 28, 2024; 16(7): 256-264
Published online Jul 28, 2024. doi: 10.4329/wjr.v16.i7.256
Published online Jul 28, 2024. doi: 10.4329/wjr.v16.i7.256
Table 1 Patient characteristics, n (%)
| Characteristics (n = 259) | |
| Age (years) | |
| Median (range) | 71 (54-87) |
| Karnofsky performance status | |
| 100 | 232 (89.5) |
| 90 | 24 (9.3) |
| 80 | 1 (0.4) |
| 60 | 2 (0.8) |
| Follow-up time (months) | |
| Median (range) | 31 (14-40) |
| Initial prostate-specific antigen (ng/mL) | |
| Median (range) | 8.23 (0.62-1354) |
| T category | |
| 1b | 1 (0.4) |
| 1c | 39 (15.1) |
| 2a | 99 (38.2) |
| 2b | 34 (13.0) |
| 2c | 57 (22.0) |
| 3a | 19 (7.3) |
| 3b | 8 (3.1) |
| 4 | 2 (0.8) |
| Gleason score | |
| 6 | 39 (15.1) |
| 7 | 119 (45.9) |
| 8 | 65 (25.1) |
| 9 | 35 (13.5) |
| 10 | 1 (0.4) |
| Diabetes mellitus | |
| Yes | 29 (11.2) |
| No | 230 (88.8) |
| Anticoagulation therapy | |
| Yes | 38 (14.7) |
| No | 221 (85.3) |
| Androgen deprivation therapy | |
| Yes | 234 (90.3) |
| No | 25 (9.7) |
| Planning target volume (cc) | |
| Median (range) | 80.71 (43.24-202.60) |
Table 2 The correlation between dose–volume parameter of rectum and rectal bleeding, mean ± SD
| Grade 0 | Grade 1/2 | P value | |
| D 6cc | 25.40 ± 7.56 Gy (RBE) | 30.93 ± 6.75 Gy (RBE) | 0.001a |
| D 2cc | 44.54 ± 2.88 Gy (RBE) | 45.93 ± 1.71 Gy (RBE) | 0.005a |
| D 0.2cc | 49.73 ± 0.98 Gy (RBE) | 49.80 ± 0.34 Gy (RBE) | 0.592 |
| V 10 Gy (RBE) | 10.45 ± 2.72 cc | 11.89 ± 2.79 cc | 0.010a |
| V 20 Gy (RBE) | 7.46 ± 2.05 cc | 8.90 ± 2.29 cc | 0.002a |
| V 30 Gy (RBE) | 5.32 ± 1.57 cc | 6.56 ± 1.78 cc | 0.001a |
| V 40 Gy (RBE) | 3.34 ± 1.05 cc | 4.15 ± 1.12 cc | 0.001a |
| V 50 Gy (RBE) | 0.18 ± 0.10 cc | 0.17 ± 0.12 cc | 0.590 |
Table 3 The comparison of ratio of rectal bleeding before and after cutoff values of dose-volume parameters calculated by using receiver operating characteristic curves
| Comparison | Number of patients | Ratio of grade 2 rectal bleeding (%) | P value | |
| D 6cc | ≥ 34.34 Gy (RBE) | 54 | 5.3 | 0.42 |
| < 34.34 Gy (RBE) | 202 | 3.0 | ||
| D 2cc | ≥ 46.46 Gy (RBE) | 65 | 7.7 | 0.047a |
| < 46.46 Gy (RBE) | 194 | 2.1 | ||
| V 10 Gy (RBE) | ≥ 9.85 cc | 136 | 5.9 | 0.038a |
| < 9.85 cc | 123 | 0.8 | ||
| V 20 Gy (RBE) | ≥ 7.00 cc | 139 | 5.8 | 0.040a |
| < 7.00 cc | 120 | 0.8 | ||
| V 30 Gy (RBE) | ≥ 6.91 cc | 48 | 6.0 | 0.374 |
| < 6.91 cc | 211 | 6.3 | ||
| V 40 Gy (RBE) | ≥ 4.26 cc | 59 | 1.7 | 0.689 |
| < 4.26 cc | 200 | 4.0 |
- Citation: Ono T, Sato H, Miyasaka Y, Hagiwara Y, Yano N, Akamatsu H, Harada M, Ichikawa M. Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer. World J Radiol 2024; 16(7): 256-264
- URL: https://www.wjgnet.com/1949-8470/full/v16/i7/256.htm
- DOI: https://dx.doi.org/10.4329/wjr.v16.i7.256