Breast cancer imaging-clinical experience with two-dimensional-shear wave elastography: A retrospective study

Table 1 Biopsy results with histopathological verification of lesions

Histopathological results	Number of lesions
Benign
Fibroadenoma	35 (17.5)
Intraductal papilloma	12 (6)
Fibro adenomatoid change	10 (5)
Mammary duct ectasia	7 (3.5)
Fibrocystic change	5 (2.5)
Complex fibroadenoma	3 (1.5)
Other benign lesions	8 (4)
Total	80 (40)
Malignant
Invasive ductal carcinoma	71 (35.5)
Ductal carcinoma in situ	30 (15)
Invasive lobular carcinoma	14 (7)
Mucinous carcinoma	2 (1)
Malignant phyllodes tumor	2 (1)
Angiosarcoma of the breast	1 (0.5)
Total	120 (60)
Total number of biopsies	200 (100)

Data are n (%).

Table 2 Detailed histological information of misclassified lesions

Biopsy results
Invasive size in mm
< 15	50 (66.7)
> 15	25 (33.3)
Histological grade
I	6 (8)
II	60 (80)
III	9 (12)
Neo vascularization
Yes	7 (9.3)
No	68 (90.7)
Nodal status
Yes	8 (10.7)
No	67 (89.3)
Mitotic index of proliferation (Ki-67)
< 3%	5 (6.7)
Between 3% and 20%	60 (80)
> 20%	10 (13.3)
Hormone receptor
Positive	60 (80)
Negative	15 (20)
Human epidermal growth factor receptor 2
Positive	40 (53.3)
Negative	35 (46.7)
Triple-negative breast cancer
Yes	10 (13.3)
No	65 (86.7)

Data are n (%).

Table 3 Diagnostic accuracy of two-dimensional-shear wave elastography + bright mode and X-ray mammography

Feature	Shear wave elastography + bright mode	X-ray mammography	Ultrasound + X-ray mammography
True positive	115	114	120
True negative	39	15	13
False positive	25	24	10
False negative	0	2	0
Sensitivity	1.00 (1.00-1.00)	0.87 (0.81–0.92)	1.00 (1.00–1.00)
Specificity	0.62 (0.52–0.76)	0.90 (0.83–0.95)	0.95 (0.83–0.95)
Positive predictive value	0.83 (0.78–0.92)	0.76 (0.80–0.92)	0.92 (0.85-0.95)
Negative predictive value	1.00 (1.00–1.00)	0.996 (0.99–1.00)	1.00 (1.00–1.00)
Accuracy	87	91	98

Data in parentheses are 95% confidence intervals.