Factors associated with gastrointestinal stromal tumor rupture and pathological risk: A single-center retrospective study

Table 1 Comparison of clinical data between unruptured and ruptured gastrointestinal stromal tumors

	Unruptured group (n = 38)	Rupture group (n = 12)	Statistical value	P value
Age (yr)	64.79 ± 9.75	57.17 ± 20.61	1.24	0.24
Gender			2.31	0.13
Male	19	9
Female	19	3
Pathological risk grade			8.47	0.02
Low risk	21	3
Intermediate risk	6	0
High risk	11	9
Tumor diameter (cm)	3.25 (2, 5.25)	9.0 (4.5, 13.63)	2.60	0.01
Tumor shape			17.56	< 0.01
Irregular	9	11
Regular	29	1
Internal necrosis			15.35	< 0.01
No	30	2
Yes	8	10
Gas-liquid interface			23.68	< 0.01
Absence	27	1
Presence	11	11
Primary site			0.23	0.63
Gastric	22	6
Small bowel	16	6
Mitotic count (50/HPF)	6.11 ± 2.60	6.17 ± 1.64	0.08	0.94
Ki-67 index (%)	5.50 (4.75, 8.00)	7.50 (5.00, 14.25)	1.15	0.25

HPF: High-power field.

Table 2 Analysis of related factors of pathological risk grade of gastrointestinal stromal tumors

	Low risk (n = 24)	Intermediate risk (n = 6)	High risk (n = 20)	χ2 value	P value
Age (yr)				1.94	0.38
< 60	5	2	8
≥ 60	19	4	12
Gender				8.10	0.02
Male	9	3	16
Female	15	3	4
Tumor diameter (cm)				10.47	0.01
< 10	22	6	11
≥ 10	2	0	9
Tumor shape				2.26	0.32
Irregular	9	1	10
Regular	15	5	10
Internal necrosis				5.37	0.07
No	18	5	9
Yes	6	1	11
Tumor rupture				8.47	0.02
No	21	6	11
Yes	3	0	9
Gas-liquid interface				0.79	0.67
Absence	15	3	10
Presence	9	3	10
Primary site				3.46	0.18
Gastric	16	4	8
Small bowel	8	2	12
Mitotic count (50/HPF)				4.49	0.11
< 5	8	3	3
≥ 5	16	2	17
Ki-67 index (%)				6.30	0.04
< 10	21	5	11
≥ 10	3	1	9

HPF: High-power field.

Table 3 Logistic regression analysis of factors associated with the pathological risk grade of gastrointestinal stromal tumors

	B	S.E.	Wald	Sig.	Exp (B)	95%CI for Exp (B)
						Lower	Upper
Age ≥ 60 yr	0.44	0.90	0.24	0.63	1.55	0.27	9.07
Male gender	2.41	0.93	6.75	0.01	11.12	1.81	68.52
Tumor diameter ≥ 10 cm	3.13	1.20	6.83	0.01	22.96	2.19	240.93
Irregular shape	0.50	1.12	0.20	0.65	1.65	0.18	14.92
Internal necrosis	-1.40	1.21	1.35	0.25	0.25	0.02	2.62
Gas-liquid interface	0.50	1.26	0.16	0.69	1.64	0.14	19.48
Small bowel tumor	-0.15	0.87	0.03	0.87	0.87	0.16	4.76
50/HPF ≥ 5	-0.33	0.87	0.14	0.71	0.72	0.13	3.96
Ki-67 index ≥ 10	2.18	1.15	3.56	0.06	8.82	0.92	84.49

95%CI: 95% confidence interval; HPF: High-power field.

Table 4 Logistic regression analysis of factors associated with rupture of gastrointestinal stromal tumors

	B	S.E.	Wald	Sig.	Exp (B)	95%CI for Exp (B)
						Lower	Upper
Age ≥ 60 yr	0.21	0.71	0.08	0.77	1.23	0.31	4.93
Male gender	-1.10	0.74	2.20	0.14	0.33	0.08	1.43
Tumor diameter ≥ 10 cm	2.27	0.77	8.72	< 0.01	9.67	2.15	43.56
Irregular shape	3.57	1.11	10.30	< 0.01	35.44	4.01	313.38
Internal necrosis	2.93	0.87	11.33	< 0.01	18.75	3.40	103.34
Gas-liquid interface	3.30	1.10	8.91	< 0.01	27.00	3.10	235.02
Small bowel tumor	-0.32	0.66	0.23	0.63	0.73	0.20	2.67
50/HPF ≥ 5	-0.84	0.85	0.97	0.33	0.43	0.08	2.29
Ki-67 index ≥ 10	1.49	0.71	4.36	0.04	4.43	1.10	17.92
High pathological risk grade	-1.31	0.74	3.12	0.08	0.27	0.06	1.16

95%CI: 95% confidence interval; HPF: High-power field.