Published online Dec 28, 2023. doi: 10.4329/wjr.v15.i12.350
Peer-review started: August 26, 2023
First decision: October 9, 2023
Revised: October 26, 2023
Accepted: December 12, 2023
Article in press: December 12, 2023
Published online: December 28, 2023
Processing time: 121 Days and 12 Hours
Gastrointestinal stromal tumor (GIST) is a rare gastrointestinal mesenchymal tumor. It is of great significance for the diagnosis, treatment, and prognosis of GIST if non-invasive examination can be performed before surgery to accurately assess the risk of tumor.
If accurate assessment of GIST tumor risk through non-invasive examination is the focus of this study, it can provide valuable insights into non-invasive examination strategies and risk assessment of GISTs.
To investigate the factors associated with GIST rupture and pathological risk, and provide insights into non-invasive examination techniques and risk assessment for GISTs.
A cohort of 50 GIST patients was selected from our hospital. Clinicopathological and CT data of the patients were collected. Logistic regression analysis was used to evaluate factors associated with GIST rupture and pathological risk grade.
Male gender and tumor diameter ≥ 10 cm were independent predictors of a high pathological risk grade of GISTs [odds ratio (OR) = 11.12, 95% confidence interval (95%CI): 1.81-68.52, P = 0.01; OR = 22.96, 95%CI: 2.19-240.93, P = 0.01]. Tumor diameter ≥ 10 cm, irregular shape, internal necrosis, gas-liquid interface, and Ki-67 index ≥ 10 were identified as independent predictors of a high risk of GIST rupture (OR = 9.67, 95%CI: 2.15-43.56, P = 0.01; OR = 35.44, 95%CI: 4.01-313.38, P < 0.01; OR = 18.75, 95%CI: 3.40-103.34, P < 0.01; OR = 27.00, 95%CI: 3.10-235.02, P < 0.01; OR = 4.43, 95%CI: 1.10-17.92, P = 0.04).
Tumor diameter, tumor morphology, internal necrosis, gas-liquid interface, and Ki-67 index are associated with GIST rupture, while gender and tumor diameter are linked to the pathological risk of GISTs. These findings contribute to our understanding of GISTs and may inform non-invasive examination strategies and risk assessment for this condition.
In later studies, we can further verify our conclusions in large-sample clinical studies to better guide clinical non-invasive examination and risk assessment of GISTs.