Padole A, Sainani N, Lira D, Khawaja RDA, Pourjabbar S, Lo Gullo R, Otrakji A, Kalra MK. Assessment of sub-milli-sievert abdominal computed tomography with iterative reconstruction techniques of different vendors. World J Radiol 2016; 8(6): 618-627 [PMID: 27358690 DOI: 10.4329/wjr.v8.i6.618]
Corresponding Author of This Article
Atul Padole, MD, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 25 New Chardon St, 4th Floor, Boston, MA 02114, United States. apadole@mgh.harvard.edu
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Prospective Study
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Padole A, Sainani N, Lira D, Khawaja RDA, Pourjabbar S, Lo Gullo R, Otrakji A, Kalra MK. Assessment of sub-milli-sievert abdominal computed tomography with iterative reconstruction techniques of different vendors. World J Radiol 2016; 8(6): 618-627 [PMID: 27358690 DOI: 10.4329/wjr.v8.i6.618]
World J Radiol. Jun 28, 2016; 8(6): 618-627 Published online Jun 28, 2016. doi: 10.4329/wjr.v8.i6.618
Assessment of sub-milli-sievert abdominal computed tomography with iterative reconstruction techniques of different vendors
Mannudeep K Kalra, Alexi Otrakji, Roberto Lo Gullo, Sarvenaz Pourjabbar, Ranish Deedar Ali Khawaja, Diego Lira, Nisha Sainani, Atul Padole
Atul Padole, Nisha Sainani, Diego Lira, Ranish Deedar Ali Khawaja, Sarvenaz Pourjabbar, Roberto Lo Gullo, Alexi Otrakji, Mannudeep K Kalra, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, United States
Nisha Sainani, Department of Radiology, Brigham and Women’s Hospital, Boston, MA 02115, United States
Author contributions: Padole A, Khawaja RDA and Pourjabbar S were involved in patient recruitment and objective measurement; Padole A and Kalra MK wrote the manuscript; Sainani N and Lira D were the readers of the study; Lo Gullo R and Otrakji A were involved in blinding of study; Kalra MK helped in consenting patients and designing the study.
Institutional review board statement: The Human Research Committee of our Institutional Review Board (IRB) approved this Health Insurance Portability and Accountability Act (HIPAA) compliant prospective clinical study.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None of the authors have any pertinent financial disclosures.
Data sharing statement: All the study participants gave written informed consent for data sharing.
Correspondence to: Atul Padole, MD, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 25 New Chardon St, 4th Floor, Boston, MA 02114, United States. apadole@mgh.harvard.edu
Telephone: +1-617-6435076 Fax: +1-617-6430111
Received: November 28, 2015 Peer-review started: November 30, 2015 First decision: December 28, 2015 Revised: January 8, 2016 Accepted: March 7, 2016 Article in press: March 9, 2016 Published online: June 28, 2016 Processing time: 203 Days and 12.4 Hours
Core Tip
Core tip: We assessed the performance of abdominal computed tomography (CT) acquired at sub-milli-Sievert radiation dose to the standard of care CT. A total of 66 subjects were scanned on three different multi-detector CT scanners at sub-milli-Sievert radiation dose [or CT dose index volume (CTDIvol) of 1.3 mGy]. Images were reconstructed with vendor-specific and vendor-neutral iterative reconstruction techniques (IRTs). We compared the clinical diagnostic performance of vendor specific and vendor neutral IRTs at sub-milli-Sievert radiation dose to the standard of care CT. We found that regardless of the IRTs and multi-detector CT vendors, CTDIvol of 1.3 mGy or sub-mill-sievert radiation dose did not provide sufficient clinical diagnostic performance for abdominal CT.
