Sepede G, Tavino M, Santacroce R, Fiori F, Salerno RM, Di Giannantonio M. Functional magnetic resonance imaging of internet addiction in young adults. World J Radiol 2016; 8(2): 210-225 [PMID: 26981230 DOI: 10.4329/wjr.v8.i2.210]
Corresponding Author of This Article
Gianna Sepede, MD, PhD, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University “A. Moro”, Piazza G. Cesare, 11, 70121 Bari, Italy. gsepede@libero.it
Research Domain of This Article
Neuroimaging
Article-Type of This Article
Systematic Reviews
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Sepede G, Tavino M, Santacroce R, Fiori F, Salerno RM, Di Giannantonio M. Functional magnetic resonance imaging of internet addiction in young adults. World J Radiol 2016; 8(2): 210-225 [PMID: 26981230 DOI: 10.4329/wjr.v8.i2.210]
World J Radiol. Feb 28, 2016; 8(2): 210-225 Published online Feb 28, 2016. doi: 10.4329/wjr.v8.i2.210
Functional magnetic resonance imaging of internet addiction in young adults
Gianna Sepede, Margherita Tavino, Rita Santacroce, Federica Fiori, Rosa Maria Salerno, Massimo Di Giannantonio
Gianna Sepede, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University “A. Moro”, 70121 Bari, Italy
Gianna Sepede, Margherita Tavino, Rita Santacroce, Federica Fiori, Rosa Maria Salerno, Massimo Di Giannantonio, Department of Neuroscience, Imaging, and Clinical Sciences, University “G.d’Annunzio”, 66100 Chieti, Italy
Author contributions: Sepede G, Salerno RM and Di Giannantonio M designed the research; Sepede G, Tavino M, Santacroce R and Fiori F performed the PubMed research, selected the papers included in the qualitative review and summarized the results; Sepede G, Salerno RM and Di Giannantonio M wrote the paper; Santacroce R performed the language editing.
Supported by Department of Neuroscience, Imaging, and Clinical Sciences, University “G.d’Annunzio”, Chieti, Italy; Dr. Sepede’s post hoc grant has been funded by the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement, No. 602450.
Conflict-of-interest statement: All authors do not report any conflict of interest. This paper reflects only the authors’ views and the European Union is not liable for any use that may be made of the information contained therein.
Data sharing statement: No additional data are available.
Correspondence to: Gianna Sepede, MD, PhD, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University “A. Moro”, Piazza G. Cesare, 11, 70121 Bari, Italy. gsepede@libero.it
Telephone: +39-0871-3556901 Fax: +39-0871-3556930
Received: July 27, 2015 Peer-review started: July 30, 2015 First decision: October 30, 2015 Revised: December 4, 2015 Accepted: December 18, 2015 Article in press: December 21, 2015 Published online: February 28, 2016 Processing time: 213 Days and 23.3 Hours
Core Tip
Core tip: We systematically reviewed the functional magnetic resonance imaging studies on adults affected by internet addiction disorder (IAD), without any other psychiatric condition. We found 18 studies, mostly conducted in East Asia and enrolling young males with internet gaming disorder. Internet addicts showed functional alterations in regions involved in cognitive control and reward/punishment sensitivity (orbitofrontal cortex, anterior and posterior cingulate, insula, dorsolateral prefrontal cortex, temporoparietal regions, brain stem and caudate nucleus) that are similar to those observed in substance use disorder. IAD is a disabling condition needing careful consideration due to its severe impact on young people’s brain functioning.
