©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Aug 28, 2015; 7(8): 212-219
Published online Aug 28, 2015. doi: 10.4329/wjr.v7.i8.212
Published online Aug 28, 2015. doi: 10.4329/wjr.v7.i8.212
Development of biodegradable radiopaque microsphere for arterial embolization-a pig study
Yi-Sheng Liu, Hong-Ming Tsai, Chen-Miao Chou, Department of Radiology, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Xi-Zhang Lin, Guan-Cheng Chen, Syuan-Fong Chen, Jui-Wen Kang, Chiung-Yu Chen, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Hung-Wen Tsai, Department of Pathology, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Author contributions: Lin XZ, Chen CY and Liu YS designed research; Liu YS, Chen GC, Chen SF and Kang JW performed research; Tsai HW contributed pathology reading; Lin XZ and Chen CY analyzed data; Chen CY and Liu YS wrote paper; all authors contributed to this paper.
Supported by The National Cheng-Kung University Hospital, No. NCKUH-102-01003.
Institutional review board statement: The experiment was approved by the ethical committee of the animal center of National Cheng Kung University (IACUC approval No. 102046).
Institutional animal care and use committee statement: The experiment was approved by the ethical committee of the animal center of National Cheng Kung University (IACUC approval No. 102046).
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Data sharing statement: No additional data are available.
Correspondence to: Chiung-Yu Chen, Medicinae Doctor, Department of Internal Medicine, College of Medicine, National Cheng Kung University, #138 Sheng-Li Road, Tainan 704, Taiwan. chiungyu@mail.ncku.edu.tw
Telephone: +886-6-2353535-2689 Fax: +886-6-2347270
Received: May 3, 2015
Peer-review started: May 3, 2015
First decision: June 18, 2015
Revised: July 7, 2015
Accepted: July 29, 2015
Article in press: August 3, 2015
Published online: August 28, 2015
Processing time: 123 Days and 4.6 Hours
Peer-review started: May 3, 2015
First decision: June 18, 2015
Revised: July 7, 2015
Accepted: July 29, 2015
Article in press: August 3, 2015
Published online: August 28, 2015
Processing time: 123 Days and 4.6 Hours
Core Tip
Core tip: Transcatheter arterial embolization (TAE) is the treatment of choice for intermediate stage hepatocellular carcinoma. Various embolization materials have been designed for this purpose. By using atomization technique and a mixture of pharmaceutical excipient, we developed a new type of calibrated, biodegradable, and imaging detectable microsphere. We proved that our microspheres, with the unique characteristics, can be used for TAE with effects equivalent to or better than Gelfoam and Embosphere in pigs.