Radiologic progression with minimal functional decline in cystic fibrosis: Insights from a prospective study

doi:10.4329/wjr.v18.i5.117936

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World Journal of Radiology

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1949-8470

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Prospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Radiol. May 28, 2026; 18(5): 117936
Published online May 28, 2026. doi: 10.4329/wjr.v18.i5.117936

Radiologic progression with minimal functional decline in cystic fibrosis: Insights from a prospective study

Jan Mohd Suhail, Mohmed Imran Wagay, Arshed Hussain Parry, Irshad Mohiuddin Bhat, Riaz Rasool Sheikh, Mushtaq Ahmad Bhat

Jan Mohd Suhail, Department of Interventional Radiology, Christian Medical College, Vellore 632002, Tamil Nādu, India

Mohmed Imran Wagay, Arshed Hussain Parry, Irshad Mohiuddin Bhat, Department of Radiodiagnosis and Imaging, Government Medical College, Srinagar 190010, Jammu and Kashmīr, India

Riaz Rasool Sheikh, Department of Radiodiagnosis and Imaging, Sher-i-Kashmir Institute of Medical Sciences, Srinagar 190001, Jammu and Kashmīr, India

Mushtaq Ahmad Bhat, Department of Pediatrics, Sher-i-Kashmir Institute of Medical Sciences, Srinagar 190001, Jammu and Kashmīr, India

Author contributions: Suhail JM, Wagay MI, Parry AH, Sheikh RR, Bhat IM, Bhat MA conceptualized the study, collected and interpreted clinical and imaging data; Parry AH, Suhail JM, Wagay MI wrote and edited the manuscript; all authors contributed to manuscript revision and provided approval for publishing the final version of the manuscript.

AI contribution statement: The use of AI tools was employed for language polishing, grammar correction, and enhancing the readability of the paper. No AI tools were utilized for data analysis, result interpretation, scientific content generation, or conclusion drawing. All scientific content, research design, data interpretation, and the final review of the paper were independently handled by the author.

Institutional review board statement: The study protocol was approved by the Institutional Ethical Committee of Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India.

Informed consent statement: Informed consent was taken from the parents or guardians of patients.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.

Data sharing statement: The original contributions presented in this study are included in the article. Further inquiries can be directed to the corresponding author.

Corresponding author: Arshed Hussain Parry, Assistant Professor, Department of Radiodiagnosis and Imaging, Government Medical College, 10 Karanagar, Srinagar 190010, Jammu and Kashmir, India. arshedparry@gmail.com

Received: December 18, 2025
Revised: February 19, 2026
Accepted: March 13, 2026
Published online: May 28, 2026
Processing time: 159 Days and 12.8 Hours

Core Tip

Core Tip: This study conducted a longitudinal follow-up of pediatric patients with cystic fibrosis (CF) using a combination of high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs). The findings demonstrated that HRCT was superior to PFTs in identifying worsening lung disease. HRCT based Bhalla scores showed a marked increase, with an approximately 50% worsening after one year of follow-up compared to baseline. In contrast, pulmonary function indices, including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio, demonstrated only minimal and statistically non-significant declines ranging from 2.9% to 5.2%. These results underscore that HRCT is a more sensitive modality than PFT for assessing disease progression in CF.