Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Aug 28, 2025; 17(8): 111076
Published online Aug 28, 2025. doi: 10.4329/wjr.v17.i8.111076
Stereotactic radiotherapy for brain metastases of non-small cell lung cancer: A comprehensive review
Aamir Khan, Hong-Fu Zhao, Hao Meng, Ning Wu, Lin-Lin Liu
Aamir Khan, Hong-Fu Zhao, Hao Meng, Ning Wu, Lin-Lin Liu, Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
Co-corresponding authors: Ning Wu and Lin-Lin Liu.
Author contributions: Khan A was responsible for extensive literature reading and manuscript writing; Zhao HF and Meng H provided technical guidance throughout the preparation of the review; Liu LL and Wu N as co-corresponding authors, proposed the research concept and provided overall supervision and strategic direction for the work.
Supported by the National Key Research and Development Program of China, No. 2022YFE0110200; Project of Science and Technology Department of Jilin Province, No. 20240501002GH and No. YDZJ202102CXJD020; Jilin University Norman Bethune Medical Department “Medicine+X” Project, No. 2022JBGS04; Project of Development and Reform Commission of Jilin Province, No. 2021C023; Department of Human Resources and Social Security Project of Jilin Province; and 20th Batch of Innovation and Entrepreneurship Talent Funding Project of Jilin Province.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ning Wu, MD, Professor, Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun 130033, Jilin Province, China. wuning@jlu.edu.cn
Received: June 23, 2025
Revised: July 16, 2025
Accepted: August 8, 2025
Published online: August 28, 2025
Processing time: 67 Days and 2.7 Hours
Core Tip

Core Tip: Stereotactic radiotherapy (SRT) offers a precise and effective treatment option for brain metastasis (BM) in patients with non-small cell lung cancer (NSCLC), providing better local tumor control, fewer side effects, and improved survival rates compared with the effects of traditional therapies. Integrating SRT with immunotherapy has displayed promise in enhancing intracranial progression-free survival, but further research is needed to optimize treatment protocols and refine multimodal therapy strategies for patients with NSCLC and BM.