Systematic Reviews
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Aug 28, 2025; 17(8): 107732
Published online Aug 28, 2025. doi: 10.4329/wjr.v17.i8.107732
Applications of photon-counting CT in oncologic imaging: A systematic review
Arosh S Perera Molligoda Arachchige, Anna Dashiell, Anton Shiraan Jesuraj, Antonia Immacolata D’Urso, Benedetta Fiore, Martina Cattaneo, Emilia Pierzynska, Sandra Szydelko, Francesca Romana Centini, Yash Verma
Arosh S Perera Molligoda Arachchige, Emergency Service, GHOL-Hopital de Nyon, Nyon 1260, Vaud, Switzerland
Anna Dashiell, Anton Shiraan Jesuraj, Antonia Immacolata D’Urso, Benedetta Fiore, Martina Cattaneo, Emilia Pierzynska, Sandra Szydelko, Francesca Romana Centini, Faculty of Medicine, Humanitas University, Pieve Emanuele 20072, Lombardy, Italy
Yash Verma, Department of Radiology, Mayo Clinic, Rochester, MN 55905, United States
Co-first authors: Arosh S Perera Molligoda Arachchige and Anna Dashiell.
Author contributions: Arachchige ASPM contributed to the conceptualization, methodology, investigation, writing the original draft, and supervision; Dashiell A contributed to methodology, data curation, reviewing, and editing; Jesuraj AS, D’Urso AI, Fiore B, Cattaneo M, Szydelko S, Centini FR, and Verma Y contributed to reviewing and editing; Pierzynska E contributed to the investigation and validation; All authors read and agreed to the published version of the manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arosh S Perera Molligoda Arachchige, MD, Emergency Service, GHOL-Hopital de Nyon, Chemin Monastier 10, Nyon 1260, Vaud, Switzerland. aroshperera@outlook.it
Received: March 28, 2025
Revised: May 4, 2025
Accepted: July 18, 2025
Published online: August 28, 2025
Processing time: 153 Days and 10.6 Hours
Core Tip

Core Tip: Photon-counting detector (PCD) CT represents a paradigm shift in oncologic imaging, offering superior spatial resolution, reduced radiation dose, and enhanced material decomposition compared with conventional CT. This study highlighted the potential of PCD CT in tumor detection, characterization, and therapy response assessment, underscoring its role in advancing precision oncology. By leveraging energy-resolved photon detection, PCD CT enhances lesion conspicuity and quantification, paving the way for improved diagnostic accuracy and personalized treatment strategies.