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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. May 28, 2025; 17(5): 104272
Published online May 28, 2025. doi: 10.4329/wjr.v17.i5.104272
Published online May 28, 2025. doi: 10.4329/wjr.v17.i5.104272
Diagnostic accuracy of noninvasive steatosis biomarkers with magnetic resonance imaging proton density fat fraction as gold standard
Jia-Liang Chen, Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
Shao-Jie Duan, Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China
Sheng Xie, Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China
Shu-Kun Yao, Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China
Author contributions: Chen JL and Yao SK designed and performed the research study; Chen JL, Duan SJ and Xie S collected and analyzed the data; Chen JL wrote the manuscript; Yao SK supervised the report; all authors reviewed and approved the final manuscript.
Supported by the Leap-forward Development Program for Beijing Biopharmaceutical Industry (G20), No. Z171100001717008; and the Fundamental Research Funds for the Central Universities and Research projects on biomedical transformation of China-Japan Friendship Hospital, No. PYBZ1815.
Institutional review board statement: This study was approved by the Clinical Research Ethics Committee of China-Japan Friendship Hospital (No. 2018-110-K79-1).
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors have no financial relationships to disclose.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Kun Yao, MD, Chief Physician, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. yao_sk@126.com
Received: December 16, 2024
Revised: March 16, 2025
Accepted: April 11, 2025
Published online: May 28, 2025
Processing time: 161 Days and 13.4 Hours
Revised: March 16, 2025
Accepted: April 11, 2025
Published online: May 28, 2025
Processing time: 161 Days and 13.4 Hours
Core Tip
Core Tip: This is the first study to investigate the accuracy of noninvasive biomarkers for detecting nonalcoholic fatty liver disease (NAFLD) based on magnetic resonance imaging proton density fat fraction (MRI-PDFF) in the Chinese population, which is currently considered the gold standard in diagnosing hepatic steatosis. Two types of cut-offs (single optimal cut-off and dual cut-off) of six steatosis biomarkers were analyzed. These noninvasive steatosis biomarkers demonstrated great accuracy in diagnosing NAFLD (MRI-PDFF ≥ 5%) and exhibited a strong correlation with MRI-PDFF. However, they may be ineffective in detecting moderate or severe steatosis.