Value of radiomics models in precision diagnosis of dual-phenotype hepatocellular carcinoma and intrahepatic cholangiocarcinoma

doi:10.4329/wjr.v17.i11.114193

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Nov 28, 2025 (publication date) through Nov 27, 2025

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World Journal of Radiology

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1949-8470

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Radiol. Nov 28, 2025; 17(11): 114193
Published online Nov 28, 2025. doi: 10.4329/wjr.v17.i11.114193

Value of radiomics models in precision diagnosis of dual-phenotype hepatocellular carcinoma and intrahepatic cholangiocarcinoma

Xu Qi, Fei-Yu Zhao

Xu Qi, Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China

Fei-Yu Zhao, Department of Radiation Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China

Author contributions: Qi X and Zhao FY contributed to manuscript writing, provided ideas for the draft, and revised the article.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Fei-Yu Zhao, PhD, Department of Radiation Oncology, The Fifth Medical Center of Chinese PLA General Hospital, No. 8 East Main Street, Fengtai District, Beijing 100071, China. 1029279130@qq.com

Received: September 17, 2025
Revised: October 3, 2025
Accepted: November 4, 2025
Published online: November 28, 2025
Processing time: 75 Days and 0.3 Hours

Core Tip

Core Tip: A recent study published by Zhang et al focuses on exploring the practical value of radiomics in ahcieving the differential diagnosis between dual-phenotype hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Its constructed combined model, with an area under the receiver operating characteristic curve of 0.892, can effectively boost diagnostic accuracy and provide significant assistance to less-experienced radiologists in clinical practice. However, the study still faces limitations of single-center data and small sample size, and future research thus needs to carry out multi-center studies and promote multi-omics fusion to address these issues.