©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Sep 28, 2020; 12(9): 204-212
Published online Sep 28, 2020. doi: 10.4329/wjr.v12.i9.204
Published online Sep 28, 2020. doi: 10.4329/wjr.v12.i9.204
Application of voxel-based morphometric method to detect brain changes in children with non-cyanotic congenital heart disease
Xuan Jia, Xiao-Hui Ma, Jia-Wei Liang, Department of Radiology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Author contributions: Jia X and Ma XH designed the study; Jia X wrote the first draft of the manuscript; Liang JW collected the data; Zhou HC performed the literature search and analysis; Mi YH conducted the statistical analysis; all authors participated in and approved the final manuscript.
Institutional review board statement: The study was approved by the Institutional Review Board of the Children's Hospital, Zhejiang University School of Medicine.
Clinical trial registration statement: The study protocol was approved by the ethics committee of the Children's Hospital of Zhejiang University School of Medicine, No. 2019-IRB-047.
Informed consent statement: The parents/legal guardians of all children provided written informed consent before their participation in this study.
Conflict-of-interest statement: The authors report no conflicts of interest. The authors are solely responsible for the content and writing of this article.
Data sharing statement: All authors agree to share the data in this article.
Corresponding author: Xuan Jia, MD, Attending Doctor, Department of Radiology, The Children's Hospital, Zhejiang University School of Medicine, No. 3333 Binsheng Road, Binjiang District, Hangzhou 310000, Zhejiang Province, China. 6202059@zju.edu.cn
Received: April 19, 2020
Peer-review started: April 19, 2020
First decision: June 5, 2020
Revised: June 7, 2020
Accepted: August 25, 2020
Article in press: August 25, 2020
Published online: September 28, 2020
Processing time: 162 Days and 1.5 Hours
Peer-review started: April 19, 2020
First decision: June 5, 2020
Revised: June 7, 2020
Accepted: August 25, 2020
Article in press: August 25, 2020
Published online: September 28, 2020
Processing time: 162 Days and 1.5 Hours
Core Tip
Core Tip: As research on the preoperative development and injury of the nervous system in patients with non-cyanotic congenital heart disease (CHD) is currently lacking, the present study aimed to determine the changes in whole-brain white matter, whole-brain gray matter, and the cerebrospinal fluid in children with CHD relative to healthy controls, by using a voxel-based morphometry technique. We hope that the results will help facilitate early clinical intervention in these children, and reduce or prevent the occurrence and progression of nervous system damage.