Masselli G, Mastroiacovo I, De Marco E, Francione G, Casciani E, Polettini E, Gualdi G. Current tecniques and new perpectives research of magnetic resonance enterography in pediatric Crohn’s disease. World J Radiol 2016; 8(7): 668-682 [PMID: 27551337 DOI: 10.4329/wjr.v8.i7.668]
Corresponding Author of This Article
Gabriele Masselli, MD, Department of Emergency Radiology, First Faculty of Medicine “La Sapienza”, University-Hospital Umberto I, Viale del Policlinico 155, 00161 Rome, Italy. gabrielemasselli@libero.it
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Gabriele Masselli, Emanuele Casciani, Elisabetta Polettini, Gianfranco Gualdi, Department of Emergency Radiology, First Faculty of Medicine “La Sapienza”, University-Hospital Umberto I, 00161 Rome, Italy
Ilaria Mastroiacovo, Giulia Francione, Department of Radiology, 2nd Faculty of Medicine “La Sapienza”, University-Sant’Andrea’s Hospital, 00189 Rome, Italy
Emidio De Marco, Department of Radiology, University Campus Bio Medico, 00128 Rome, Italy
Author contributions: Masselli G designed the study and wrote the manuscript; Mastroiacovo I helped to write the manuscript; De Marco E, Francione G, Casciani E, Polettini E and Gualdi GF provided the collection of part of the material; all the authors were also involved in editing the manuscript.
Conflict-of-interest statement: All authors declare that there don’t have any conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Gabriele Masselli, MD, Department of Emergency Radiology, First Faculty of Medicine “La Sapienza”, University-Hospital Umberto I, Viale del Policlinico 155, 00161 Rome, Italy. gabrielemasselli@libero.it
Telephone: +39-06-49979465
Received: September 27, 2015 Peer-review started: October 6, 2015 First decision: January 15, 2016 Revised: March 24, 2016 Accepted: April 7, 2016 Article in press: April 11, 2016 Published online: July 28, 2016 Processing time: 301 Days and 17.5 Hours
Abstract
Crohn’s disease affects more than 500000 individuals in the United States, and about 25% of cases are diagnosed during the pediatric period. Imaging of the bowel has undergone dramatic changes in the past two decades. The endoscopy with biopsy is generally considered the diagnostic reference standard, this combination can evaluates only the mucosa, not inflammation or fibrosis in the mucosa. Actually, the only modalities that can visualize submucosal tissues throughout the small bowel are the computed tomography (CT) enterography (CTE) with the magnetic resonance enterography (MRE). CT generally is highly utilized, but there is growing concern over ionizing radiation and cancer risk; it is a very important aspect to keep in consideration in pediatric patients. In contrast to CTE, MRE does not subject patients to ionizing radiation and can be used to detect detailed morphologic information and functional data of bowel disease, to monitor the effects of medical therapy more accurately, to detect residual active disease even in patients showing apparent clinical resolution and to guide treatment more accurately.
Core tip: Magnetic resonance enterography is an effective imaging modality to diagnosis, evaluating and follow-up of Crohn’s disease (CD) in pediatric patient and novel magnetic resonance imaging application, such as motility studies, spectroscopy, diffusion weighted imaging, molecular and hybrid imaging are extremely interesting and might contribute to diagnosis and managment of CD.
