Ali S, Fedenko A, Syed AB, Matcuk G, Patel D, Gottsegen C, White E. Bilateral primary xanthoma of the humeri with pathologic fractures: A case report. World J Radiol 2013; 5(9): 345-348 [PMID: 24198913 DOI: 10.4329/wjr.v5.i9.345]
Corresponding Author of This Article
Sayed Ali, MD, Department of Radiology, Temple University Hospital, 3401 N. Broad St. Philadelphia, PA 19140, United States. alisayan@tuhs.temple.edu
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Radiol. Sep 28, 2013; 5(9): 345-348 Published online Sep 28, 2013. doi: 10.4329/wjr.v5.i9.345
Bilateral primary xanthoma of the humeri with pathologic fractures: A case report
Sayed Ali, Alex Fedenko, Ali B Syed, George Matcuk, Dakshesh Patel, Chris Gottsegen, Eric White
Sayed Ali, Ali B Syed, Department of Radiology, Temple University Hospital, 3401 N. Broad St. Philadelphia, PA 19140, United States
Alex Fedenko, Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, United States
George Matcuk, Dakshesh Patel, Chris Gottsegen, Eric White, Department of Radiology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, United States
Author contributions: Ali S prepared the manuscript, edited the images and edited the revision; Fedenko A submitted the pathology image, and provide the pathology interpretation; Syed AB edited the manuscript and references; Matcuk G, Patel D and Gottsegen C provided opinions on the manuscript style and content, edited the manuscript and provided clinical information; White E edited the manuscript, provided the images and the clinical data.
Correspondence to: Sayed Ali, MD, Department of Radiology, Temple University Hospital, 3401 N. Broad St. Philadelphia, PA 19140, United States. alisayan@tuhs.temple.edu
Telephone: +1-215-7076847 Fax: +1-215-7075294
Received: May 27, 2013 Revised: August 9, 2013 Accepted: August 28, 2013 Published online: September 28, 2013 Processing time: 126 Days and 19.5 Hours
Abstract
Xanthomas are rare bone tumors that occur more often in the appendicular skeleton and typically appear radiographically benign, with a narrow zone of transition and a sclerotic rim. We report the case of a 57-year-old woman with hyperlipidemia presenting with bilateral shoulder pain after minor trauma. Radiographic and histopathologic investigation demonstrated intraosseous xanthoma with atypical features, including multifocality, a wide zone of transition and pathologic fractures-characteristics more commonly associated with aggressive lesions such as multiple myeloma or metastasis. The diagnosis, imaging, and histological appearance of xanthoma of bone are reviewed.
Core tip: Primary xanthoma of bone is very rare, and the clinical and radiological presentation of this case is distinctly uncommon. This condition can occur in patients with both normal and abnormal lipid profiles. The radiological features are protean and can appear both aggressive and nonaggressive, hence the diagnosis can usually only be made with a biopsy.
