Published online Jul 28, 2022. doi: 10.4329/wjr.v14.i7.238
Peer-review started: February 14, 2022
First decision: April 8, 2022
Revised: May 6, 2022
Accepted: July 5, 2022
Article in press: July 5, 2022
Published online: July 28, 2022
Processing time: 162 Days and 12.4 Hours
Renal sympathetic denervation (RSD) provides a minimally invasive interventional treatment modality for patients with resistant hypertension. However, the post-operative outcomes remain a key area of investigation since its earliest clinical trials.
To evaluate patient outcomes after RSD intervention among peer-reviewed patient cases.
A systematic review of literature on MEDLINE, Google Scholar, and the Cochrane Database of Systematic Reviews for RSD case studies to assess post-operative hypertension readings and medical management.
Among 51 RSD cases, the post-operative RSD patients report an apparent reduction with a mean number of 3.1 antihypertensive medications. The mean systolic arterial blood pressure 1 year following RSD was 136.0 mmHg (95%CI: 118.7-153.3).
The apparent improvements in office systolic blood pressure after 12 month post-operative RSD can support the therapeutic potential of this intervention for blood pressure reduction. Additional studies which utilized a uniform methodology for blood pressure measurement can further support the findings of this systematic review.
Core Tip: This is the first systematic review focused on peer-reviewed clinical case reports in the topic area of renal sympathetic denervation in hypertension outcomes. In addition, this study has noted the changes in blood pressure medication regimens for the management of resistant hypertension.