Landiolol modulates sodium 1.5 ion and connexin-43 to reduce sepsis ventricular arrhythmias

doi:10.4330/wjc.v18.i3.117821

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Mar 26, 2026 (publication date) through Mar 23, 2026

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Cardiol. Mar 26, 2026; 18(3): 117821
Published online Mar 26, 2026. doi: 10.4330/wjc.v18.i3.117821

Table 1 Comparison of tumor necrosis factor-α and interleukin-6 expression levels in the three groups

Group	TNF-α (ng/L)	IL-6 (ng/L)
Control (n = 8)	299.86 ± 20.43	0.34 ± 0.03
Sepsis (n = 8)	571.35 ± 69.12^a	0.78 ± 0.08^a
Sepsis + landiolol (n = 8)	395.66 ± 72.28^a^,^b	0.56 ± 0.06^a^,^b
F	43.667	29.150
P value	< 0.001	< 0.001

^aP < 0.05 vs control.

^bP < 0.05 vs sepsis group.

TNF-α: Tumor necrosis factor-α; IL-6: Interleukin-6.

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Citation: Hu PF, Bai LY, Zhao M, Ma KY, Xuan LY, Qi X. Landiolol modulates sodium 1.5 ion and connexin-43 to reduce sepsis ventricular arrhythmias. World J Cardiol 2026; 18(3): 117821
URL: https://www.wjgnet.com/1949-8462/full/v18/i3/117821.htm
DOI: https://dx.doi.org/10.4330/wjc.v18.i3.117821