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World J Cardiol. Mar 26, 2026; 18(3): 117821
Published online Mar 26, 2026. doi: 10.4330/wjc.v18.i3.117821
Published online Mar 26, 2026. doi: 10.4330/wjc.v18.i3.117821
Landiolol modulates sodium 1.5 ion and connexin-43 to reduce sepsis ventricular arrhythmias
Peng-Fei Hu, School of Graduate Studies, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Peng-Fei Hu, Department of Cardiology, Affiliated Hospital of Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, China
Ling-Yu Bai, Ming Zhao, Kui-Ying Ma, Department of Cardiovascular Medicine, Affiliated Hospital of Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, China
Li-Ying Xuan, School of Medicine, Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, China
Xin Qi, Department of Cardiology, Tianjin Union Medicine Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China
Co-first authors: Peng-Fei Hu and Ling-Yu Bai.
Author contributions: Hu PF and Bai LY conducted the research, formal analysis, and writing - original draft and they contributed equally to this manuscript and are co-first authors; Zhao M and Ma KY conducted the investigation, conceptualization, and methodology; Xuan LY conducted data curation and formal analysis; Qi X designed the research, and contributed to formal analysis, project administration and writing - review and editing. All authors have read and approved the final version to be published.
Supported by Inner Mongolia Natural Science Foundation Project of China, No. 2020MS08031, No. 2021MS08069, and No. 2023 LHMS08082; and Education Institutions in Inner Mongolia Autonomous Region of China, No. NJZY22456.
Institutional animal care and use committee statement: All animal procedures followed the guidelines of the Medical Ethics Committee of Affiliated Hospital of Inner Mongolia Minzu University (No. NM-LL-2024-04-01-04).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The author stated that the data of this study can be obtained by contacting the corresponding author under reasonable circumstances.
Corresponding author: Xin Qi, Chief Physician, Department of Cardiology, Tianjin Union Medicine Center, The First Affiliated Hospital of Nankai University, No. 190 Jieyuan Road, Hongqiao District, Tianjin 300121, China. qixinx2011@126.com
Received: December 17, 2025
Revised: January 4, 2026
Accepted: February 9, 2026
Published online: March 26, 2026
Processing time: 96 Days and 22.3 Hours
Revised: January 4, 2026
Accepted: February 9, 2026
Published online: March 26, 2026
Processing time: 96 Days and 22.3 Hours
Core Tip
Core Tip: Landiolol, a beta-blocker, can treat ventricular arrhythmias caused by sepsis. In this study, a rat sepsis model was first established, and the animals then received landiolol. Cardiac electrophysiological experiments and ultrastructural observations of the myocardium were conducted to clarify the electrophysiological effects and mechanisms of landiolol on ventricular myocytes in septic rats. It showed that landiolol could reduce the occurrence of ventricular arrhythmias in sepsis rats through inhibiting inflammatory cells, reducing myocardial fibrosis, reversing ventricular remodeling, and decreasing the expression of connexin-43 and sodium 1.5 ion.