Logistic regression-based risk prediction of aortic adverse remodeling following thoracic endovascular aortic repair in patients with aortic dissection

Table 1 Baseline characteristics of type B aortic dissection patients stratified by aortic remodeling status, n (%)/mean ± SD

	Favorable remodeling group (n = 95)	Adverse remodeling group (n = 45)	t/χ²	P value
Sex
Male	49 (51.58)	22 (48.89)	0.088	0.766
Female	46 (48.42)	23 (51.11)
Age	57.37 ± 13.97	56.84 ± 14.34	0.205	0.837
Comorbidity
Hypertension	90 (94.74)	39 (86.67)	2.75	0.097
Diabetes	46 (48.42)	23 (51.11)	0.088	0.766
Coronary heart disease	34 (35.79)	14 (31.11)	0.297	0.586
Hyperlipidaemia	37 (38.95)	15 (33.33)	0.412	0.521
Chronic renal failure	7 (7.37)	4 (8.89)	0.098	0.755
Smoking history	29 (30.53)	10 (22.22)	1.048	0.306
Alcohol consumption	19 (20)	12 (26.67)	0.787	0.375
Pain location
Chest pain/Back pain	47 (49.47)	24 (53.33)	0.182	0.670
Abdominal pain	10 (10.53)	6 (13.33)	0.238	0.626
Chest and abdominal pain	38 (40)	15 (33.33)	0.577	0.448
BMI	23.64 ± 7.64	22.15 ± 9.45	1.042	0.299

BMI: Body mass index.

Table 2 Comparison of imaging and surgical data between groups, n (%)/mean ± SD

	Favorable remodeling group (n = 95)	Adverse remodeling group (n = 45)	t/χ²	P value
True lumen diameter at primary entry tear	14.45 ± 4.69	11.13 ± 3.68	4.137	0.001
False lumen diameter at primary entry tear (mm)	17.05 ± 2.05	20.42 ± 3.58	-7.061	0.001
True lumen diameter at T12 level (mm)	12.66 ± 3.62	10.24 ± 3.28	3.804	0.001
False lumen diameter at T12 level (mm)	15.20 ± 1.85	19.58 ± 2.77	-11.060	0.001
Extent of false lumen involvement
Thoracic aorta	7 (7.37)	0	7.461	0.024
Suprarenal abdominal aorta	41 (43.16)	13 (28.89)
Thoracoabdominal aorta	47 (49.47)	32 (71.11)
Branch vessels from false lumen	1.95 ± 0.66	2.49 ± 0.84	-4.143	0.001
Entry tears in descending aorta	3.04 ± 0.82	3.13 ± 0.82	-0.614	0.540
Entry tears in abdominal aorta	1.95 ± 0.66	1.93 ± 0.65	0.118	0.906
Patency of false lumen	34 (35.79)	29 (64.44)	10.131	0.002
Timing of surgery
Acute phase	4 (4.21)	9 (20)	17.672	0.001
Subacute phase	88 (92.63)	29 (64.44)
Chronic phase	3 (3.16)	7 (15.56)
Operative duration (minute)	70.56 ± 15.12	69.73 ± 17.88	0.063	0.95
Intraoperative blood loss (mL)	29.47 ± 12.93	32.12 ± 15.24	-0.224	0.823
Left subclavian artery revascularization
Performed	33 (34.74)	19 (42.22)	0.733	0.392
Not performed	62 (65.26)	26 (57.78)

Table 3 Multivariable logistic regression analysis of aortic adverse remodeling predictors

Variable1	β	SE	Wald χ²	OR	95%CI	P value
True lumen diameter at primary entry tear	-0.071	0.094	0.576	0.931	0.774-1.120	0.448
False lumen diameter at primary entry tear (mm)	0.445	0.135	10.820	1.561	1.197-2.035	0.001
True lumen diameter at T12 level (mm)	-0.103	0.103	1.000	0.902	0.736-1.104	0.317
False lumen diameter at T12 level (mm)	0.589	0.165	12.807	1.564	0.894-1.766	0.001
False lumen involvement: Thoracic aorta	-0.314	0.075	7.125	0.925	0.614-0.831	0.015
False lumen involvement: Suprarenal abdominal aorta	-0.369	0.751	0.242	0.691	0.159-3.011	0.023
False lumen involvement: Thoracoabdominal aorta	8.545	12.254	24.687	11.751	9.841-15.612	0.001
Branch vessels from false lumen	0.467	0.517	0.816	1.595	0.579-4.390	0.366
Patency of false lumen	1.730	0.721	5.751	5.639	4.372-8.181	0.004
Acute phase intervention	1.476	0.284	5.118	1.175	0.886-1.925	0.045
Subacute phase intervention	-1.497	1.104	1.839	0.224	0.026-1.947	0.175
Chronic phase intervention	-1.248	0.856	1.125	0.287	0.014-1.537	0.145

¹Categorical variables were coded as follows: False lumen involvement (Reference: Thoracic aorta): Suprarenal abdominal aorta (Present = 1, Absent = 0), Entire aorta (Present = 1, Absent = 0). Timing of surgery (Reference: Subacute phase): Acute phase (Yes = 1, No = 0), Chronic phase (Yes = 1, No = 0).