Prognostic impact of prediabetic glycated hemoglobin levels in nondiabetic patients undergoing percutaneous coronary intervention: A systematic review and meta-analysis

Table 1 Baseline characteristics of included studies

Ref.	Country	Sample size	Mean age in years (MD)	Males %	Normal HbA1c	Abnormal HbA1c	Follow up	Cardiac diagnosis	Study outcomes
Aggarwal et al[13]	United States	1163 (652 vs 511)	NR	NR	< 5.7	5.7 < HbA1c < 6.5	3 years	STEMI	All-cause deaths
Chen et al[15]	China	267 (64 vs 263)	NR	83.5	< 6	6.0 < HbA1c < 6.5	178 days	STEMI/NSTEMI	All-cause deaths, repeated PCI, recurrent AMI, HF requiring hospitalization
Dykun et al[17]	Germany	1692 (1188 vs 510)	66.1 (11.4)	77.1	6.3 (1.2)	≥ 7.8%	2.8 years	STEMI/NSTEMI	association of HbA1c with ACM in unadjusted and multivariable adjusted modeling
Kok et al[16]	Netherland	2103 (234 vs 1869)	NR	NR	< 6	6.0 < HbA1c < 6.5	1 year	Obstructive coronary disease	All-cause deaths, MI, revascularization, and stent thrombosis)
Naito et al[12]	Japan	452 (231 vs 221)	NR	NR	< 5.7	5.7 < HbA1c < 6.5	4.7 years	ACS	Primary endpoint was a composite of all-cause death and non-fatal MI
Park et al[18]	South Korea	1318 (120 vs 1198)	64.8 (8.9) vs 60.6 (11.3)	48.02	< 5.7	6.5 ≤ HbA1c < 7.0	1.83 years	CAD	Survival free from MACE
Shin et al[14]	South Korea	2470 (1475 vs 995)	NR	NR	< 5.7	5.7 < HbA1c < 6.5	1 year	STEMI	All-cause deaths, MACEs (all-cause mortality, non-fatal MI, TLR, TVR)
Timmer et al[11]	Netherland	4176 (1024 vs 3152)	62 (13) vs 63 (13)	74	< 5.8	> 5.8	3.3 ± 1.5 years	STEMI	30-day mortality, 1-year mortality, and infarct size
Wen et al[19]	China	7033 (3530 vs 3503)	NR	74.3	< -0.506	≥ 0.179	2 years	ACS + SCAD	Mortality, ACM, CM, MACEs, MACCEs
Zhou et al[20]	China	11729 (4976 vs 6753)	51.78 (6.97) vs 49.07 (7.21)	71.9	< 5	> 6	4.62 years	Premature CAD	Long-term all-cause mortality, cardiac mortality

PCI: Percutaneous coronary intervention; ACM: All-cause mortality; CM: Cardiac mortality; MACE: Major adverse cardiac event; MI: Myocardial infarction; MACCE: Major adverse cardiac and cerebrovascular events; NR: Not reported; TLR: Target lesion revascularization; NSTEMI: Non-ST segment elevation myocardial infarction; STEMI: ST-segment elevation myocardial infarction; ACS: Acute coronary syndrome; CAD: Coronary artery disease; SCAD: Stable coronary artery disease; HbA1c: Glycated hemoglobin.