Systematic Reviews
Copyright ©The Author(s) 2022.
World J Cardiol. Sep 26, 2022; 14(9): 483-495
Published online Sep 26, 2022. doi: 10.4330/wjc.v14.i9.483
Table 1 Baseline characteristics of the included studies
Ref.
Setting
Country of origin
Multicenter
n
Enrolment period
Mean age
Male (%)
LVEF (%)
Oebel et al[25], 2017PVCs ablationGermanyNo1012015-2016575946
Sakamoto et al[24], 2015VT/VFJapanNo34-607145
Piers et al[26], 2016NICMNetherlandsNo402011-578330
Becker et al[27], 2020DCMNetherlandsNo1652016-2018596236
Cho et al[29], 2017Duchenne muscular dystrophyKoreaNo37-16-55
Cardona et al[28], 2019Myotonic dystrophy 1United StatesNo522012-2017413860
Nadour et al[30], 2014MIUnited StatesNo2352006-2009628233
Chew et al[31], 2018MICanadaNo7052011-2014648440
Ciuffo et al[32], 2020AFUnited StatesNo1522010-2015607657
Ferrero et al[33], 2020MyocarditisItalyYes802008-2019348255
Fischer et al[34], 2020MyocarditisSwitzerlandNo5872002-2015485948
Inoue et al[35], 2017General populationUnited StatesYes16692000 - 2002675062
De Lazzari et al[37], 2018ACItalyNo792006-2016336058
Mewton et al[38], 2016HFpEFUnited StatesNo772009-2010606860
Sobue et al[39], 2015SarcoidosisJapanNo592006-20102951
Wieslander et al[36], 2015General populationUnited StatesNo1932011-2013636649
Wieslander et al[40], 2018LBBBUnited StatesYes325-635236
Bi et al[9], 2020HCMChinaNo692015-2020466265
Chen et al[10], 2014HCMChinaNo1182005-2012467272
Chen et al[11], 2020HCMChinaNo1352012-2016515162
Riza-Demir et al [12], 2019HCMTurkeyNo742016-2018516566
Dohy et al[13], 2020HCMHungaryNo181-495763
Fronza et al[14], 2016HCMItalyNo882004-2014427462
Grall et al[15], 2014HCMFranceNo422008-2012477262
Guerrier et al[16], 2016Pediatric HCMUnited StatesNo372006-2014168969
Kawasaki et al[17], 2015HCMJapanNo602010-2013667664
Konno et al[18], 2015HCMJapanNo1082008 - 20146265-
Matsuki et al[19], 2020HCMJapanNo41-627665
Park et al[20], 2018HCMKoreaNo88-57746
Sakamoto et al[21], 2015HCMJapanNo422004-2014597958
Suwa et al[22], 2014HCMJapanYes502004 - 2012---
Tangwiwat et al[23], 2019HCMThailandNo1442005 - 2015666073
Table 2 Summary of the main findings of all included studies in the systematic review
Ref.
ECG markers studied
Main findings
Bi et al[9], 2020fQRS, AF, bundle branch blockQuantitative fQRS was an independent predictor for myocardial fibrosis in HCOM
Chen et al[10], 2014ST and T waves, LVH, Q waves, 1° AV block, 2° and 3° AV block, QRS durationAbnormal Q waves were related to basal anteroseptal hypertrophy and extensive segmental LGE in HCM
Chen et al[11], 2020QRS duration, QTc, LVH, RBBB, LAFB, LBBB, Selvester scoreSelvester score showed a significant positive correlation with the extent of LGE enhancement in HCM
Riza Demir et al[12], 2019QRS duration, QTc, TP-e interval, TP-e/QTcTp-e interval was an independent predictor of LGE in HCM
Dohy et al[13], 2020fQRS, Q wave, ST deviation, Sokolow, Cornell, and Romhilt-Estes scorefQRS and ST deviation (strain pattern) predicts myocardial fibrosis in HCM
Fronza et al[14], 2016Q waves, LBBB, signs of LV hypertrophy, negative T waves, ST depressionNegative T waves were correlated with LGE, whereas Q waves were associated with asymmetric hypertrophy in HCM
Grall et al[15], 2014AF, QRS duration, ST deviation, negative T wave, Q wave, Sokolow, Cornell, Romhilt-Estes scoreQ waves were more prevalent in the presence of LGE but didn´t correlate with LGE location and extent in HCM
Guerrier et al[16], 2016QRS axis, QTc, PR interval, T wave inversion, ST depression, Q waves, LVHLow left ventricle precordial voltages in ECG were associated with LGE in pediatric HCM patients
Kawasaki et al[17], 2016QRS duration and axis, QTc, AF, LVH, Q wave, ST deviation, T wave inversion, notched QRSNotched QRS was correlated with LGE in HCM without LBBB
Konno et al[18], 2015Pathological Q waves and fQRSfQRS was correlated with LGE in HCM, whereas Q waves were not correlated with LGE
Matsuki et al[19], 2020QT interval, QRS duration, Sum of R-wave amplitude, ventricular late potentialsVentricular late potentials were not correlated with LGE in HCM
Park et al[20], 2018QRS, QTc, biphasic T wave, Q waves, sum S V1-3, Sokolow, Cornell, fQRS, AF, giant T wave inversionThe number of fQRS leads was significantly correlated to LGE in HCM
Sakamoto et al[21], 201524-hour ECG recordings and Time-domain T-wave alternans and QT dispersionT-wave alternans and QT dispersion were associated with LGE in HCM
Suwa et al[22], 2014QRS, QTc, Sokolov, max ST, max T waves, fQRSfQRS was associated with impaired apical contraction and apical LGE in HCM
Tangwiwat et al[23], 2019QRS duration, QTc, QRS axis, T-wave inversion, Sokolov, CornellfQRS in HCM was found to be associated with myocardial fibrosis in univariate analysis but not in the multivariate analysis
Sakamoto et al[24], 2015HR, QT, QTc, QTe/RR slope, QTa/RR slope, day/night slope, VT/FVQTe day/night and QTa day/night ratios were significantly greater in patients with Ventricular Arrhythmias and LGE
Oebel et al[25], 2017PVC morphologiesRBBB, LBBB morphology and multiple PVC morphologies were associated with LGE in patients undergoing PVC ablation
Piers et al[26], 2016Prolongation of the paced QRS duration after premature stimulation QRS duration was associated with ventricular tachycardia but not with LGE in non-ischemic cardiomyopathy
Becker et al[27], 2020HR, AV delay, 1° AV block, QRS duration, LBBBQRS-prolongation was not correlated with LGE in non-ischemic dilated cardiomyopathy
Cardona et al[28], 2017PR, QRS, QT, QTc, Frontal QRS-T angle, LVH CornellSurface conduction abnormality was not associated with LGE in myotonic muscular dystrophy type 1
Cho et al[29], 2019fQRSf-QRS was correlated with LGE in Duchenne muscular dystrophy with low statistical significance levels
Nadour et al[30], 2014Q wavesQ waves in ECG have low value to detect a past myocardial infarction in the general population
Chew et al[31], 2018QRS 120 ms, QRS fragmentation, Axis, AFfQRS was associated with increased peri-infarct zone LGE and unfavorable left ventricle remodeling
Ferrero et al[33], 2020fQRSfQRS was correlated with LGE in patients with myocarditis
Fischer et al[34], 2020QTc, QRS-T angle, fQRS, BBB, ST deviation, PR depression, low voltage, Q and T wavefQRS, low voltage and QRS-T angle > 90° were independently correlated with LGE in myocarditis
Inoue et al[35], 2020QRS duration, QTc, Sokolov and CornellQRS Cornell voltage, QRS duration, and QTc were significantly associated with LGE presence, while QRS Sokolow-Lyon voltage was not shown a significant correlation with LGE-CMR
Wieslander et al[36], 2015LBBB, RBBB, LAFB, RBBB + LAFB and Selvester scoreSelvester score was not accurate to detect myocardial scar and LGE in patients with conduction abnormalities and BBB
De Lazzari et al[37], 2018Depolarization and repolarization abnormalitiesLow QRS voltages in limb leads predicted LGE in Arrhythmogenic Cardiomyopathy
Mewton et al[38], 2016QRS d, QTc, QRS-T angle, QRS score, T wave alternansA significant association between T-wave alternans value and total scar. Patients with a myocardial ischemic scar had greater QRS duration. QRS-T angle was not associated with total myocardial scar size, core of scar, and gray zone size in grams by LGE-CMR
Sobue et al[39], 2015QRS duration, atrioventricular block, LAFB, RBBB, Selvester QRS scoreSelvester score was correlated with LGE in cardiac sarcoidosis
Wieslander et al[40], 2018LBBBSelvester score was not accurate to detect myocardial scar and LGE in patients with LBBB
Ciuffo et al[32], 2020Inter-atrial blockAdvanced IAB is associated with more fibrosis, while longer P-wave duration is also associated with more LA fibrosis.