Cardiovascular and nonalcoholic fatty liver disease: Sharing common ground through SIRT1 pathways

Figure 1 Silent mating type information regulation 2 homolog 1 is an integral pathway for metabolic disorders such as diabetes mellitus and the clinical outcomes for cardiovascular disease and nonalcoholic fatty liver disease. The silent mating type information regulation 2 homolog 1 (SIRT1; Saccharomyces cerevisiae) and the complementary pathways of SIRT1 that include nicotinamide, erythropoietin, nicotinamide adenine dinucleotide, and AMP-activated protein kinase function to maintain glucose homeostasis during metabolic disorders such as diabetes mellitus, Ultimately, the pathways of SIRT1 impact cardiovascular disease by promoting stem cell function, enhancing cellular energy repletion, and preventing coronary artery disease and influence nonalcoholic fatty liver disease by inhibiting insulin resistance, lipogenesis, and hepatic steatosis. SIRT1: Silent mating type information regulation 2 homolog 1; NAD⁺: Nicotinamide adenine dinucleotide; EPO: Erythropoietin; AMPK: AMP-activated protein kinase; NAFLD: Nonalcoholic fatty liver disease.