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World J Cardiol. Jul 26, 2026; 18(7): 120097
Published online Jul 26, 2026. doi: 10.4330/wjc.v18.i7.120097
Published online Jul 26, 2026. doi: 10.4330/wjc.v18.i7.120097
Landiolol attenuates atrial remodeling in septic rats by upregulating calumenin
Zhi-Hui He, School of Basic Medical Sciences, Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, China
Lian-Kui Wu, Intensive Care Unit, Affiliated Hospital of Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, China
Hao Liu, Section of Anatomy, Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, China
Ling-Yu Bai, Kui-Ying Ma, Ming Zhao, Department of Cardiovascular Medicine, Affiliated Hospital of Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, China
Jian-Jun Du, Department of Cardiovascular Medicine, The First People’s Hospital of Horqin District, Tongliao 028000, Inner Mongolia Autonomous Region, China
Yu Wang, Key Laboratory of Basic Pharmacology of the Ministry of Education, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Co-corresponding authors: Yu Wang and Ming Zhao.
Author contributions: He ZH conducted the research, investigation, formal analysis, and writing original draft; Wu LK contributed to investigation, conceptualization, and methodology; Liu H contributed to validation, visualization, and formal analysis; Bai LY, Du JJ and Ma KY contributed to data curation, and formal analysis; Wang Y and Zhao M designed the research, and contributed to formal analysis, project administration, and writing review and editing, contributed equally to this study as co-corresponding authors; all authors have read and approved the final version to be published.
AI contribution statement: All the research content, academic viewpoints, experimental data and professional terminology remain unchanged and unused AI.
Supported by Natural Science Foundation of Inner Mongolia Autonomous Region of China, No. 2023LHMS08082, No. 2018MS08036, and No. 2021MS08069; and Scientific Research in Higher Education Institutions of the Inner Mongolia Autonomous Region, China, No. NJZY22456.
Institutional animal care and use committee statement: This study was approved by the Medical Ethics Committee of Affiliated Hospital of Inner Mongolia Minzu University (approval No. NM-LL-2024-04-01-36).
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Corresponding author: Ming Zhao, PhD, Chief Physician, Department of Cardiovascular Medicine, Affiliated Hospital of Inner Mongolia Minzu University, No. 22 Holin He Street, Tongliao 028000, Inner Mongolia Autonomous Region, China. langzhe73@163.com
Received: February 24, 2026
Revised: March 13, 2026
Accepted: May 28, 2026
Published online: July 26, 2026
Processing time: 153 Days and 3.9 Hours
Revised: March 13, 2026
Accepted: May 28, 2026
Published online: July 26, 2026
Processing time: 153 Days and 3.9 Hours
Core Tip
Core Tip: This study first established a sepsis rat model and validated the modeling success by detecting elevated serum inflammatory cytokine levels using enzyme-linked immunosorbent assay. The model was treated with landiolol to compare the degree of inflammatory injury, myocardial fibrosis, and changes in atrial electrophysiology among the different groups. Immunofluorescence, immunohistochemistry, and Western blot analyses were performed to detect the expression of apoptosis-related proteins and endoplasmic reticulum stress-related proteins (glucose-regulated protein 78 and C/EBP homologous protein) and calumenin. The results indicated that landiolol may protect the myocardium by upregulating calumenin expression, thereby mitigating atrial electrical and structural remodeling in sepsis rats.