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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jan 26, 2026; 18(1): 114123
Published online Jan 26, 2026. doi: 10.4330/wjc.v18.i1.114123
Published online Jan 26, 2026. doi: 10.4330/wjc.v18.i1.114123
Comparison of 6% hydroxyethyl starch 130/0.4 vs 5% albumin in cardiopulmonary bypass for cardiac surgery
Ahmed Alqarni, Abdulwahab Algarni, Department of Cardiology, King Abdullah Medical Complex, Ministry of Health, Jeddah 22434, Makkah al Mukarramah, Saudi Arabia
Rejina Chhetri, Department of Cardiology, Nepalgunj Medical College, Kohal 21900, Nepal
Author contributions: Alqarni A and Algarni A contributed to the conceptualization and methodology and drafted the original manuscript; Alqarni A, Algarni A, and Chhetri R contributed to data curation, formal analysis, manuscript review and editing; All authors approved the final version of the manuscript.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rejina Chhetri, Department of Cardiology, Nepalgunj Medical College, Das Bigha, Kohalpur - 11, Kohal 21900, Nepal. rejinachhetri01@gmail.com
Received: September 15, 2025
Revised: September 22, 2025
Accepted: December 1, 2025
Published online: January 26, 2026
Processing time: 125 Days and 16.3 Hours
Revised: September 22, 2025
Accepted: December 1, 2025
Published online: January 26, 2026
Processing time: 125 Days and 16.3 Hours
Core Tip
Core Tip: This meta-analysis systematically compared 6% hydroxyethyl starch 130/0.4 and 5% human albumin as priming and volume replacement fluids in cardiac surgery with cardiopulmonary bypass. It highlighted comparable safety and efficacy profiles between the two colloids in terms of bleeding, transfusion needs, intensive care unit stay, and mortality while identifying a higher risk of acute kidney injury associated with hydroxyethyl starch. These findings challenge traditional preferences and emphasize the need for individualized fluid choice guided by patient factors and evolving regulatory considerations in perioperative cardiac care.