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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jan 26, 2026; 18(1): 112827
Published online Jan 26, 2026. doi: 10.4330/wjc.v18.i1.112827
Published online Jan 26, 2026. doi: 10.4330/wjc.v18.i1.112827
Kounis syndrome type III triggered by stents in patients with coronary artery disease: A review of clinical cases
Kristina G Pereverzeva, Sergey S Yakushin, Ayoub Glenza, Arzu A Gurbanova, Department of Hospital Therapy with a Course in Medical and Social Expertise, Federal State Budgetary Educational Institution of Higher Education I.P. Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation, Ryazan 390026, Russia
Author contributions: Pereverzeva KG performed the study conceptualization, methodology, data curation, drafting of the manuscript and editing of the subsequent versions, and supervision of the project; Yakushin SS provided critical resources and performed project administration; Glenza A performed the literature review and data validation; Gurbanova AA performed the formal investigations and data analyses; Yakushin SS, Glenza A, and Gurbanova AA contributed to the reviewing and editing of the various manuscript versions; and all authors read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kristina G Pereverzeva, MD, PhD, Associate Professor, Department of Hospital Therapy with a Course in Medical and Social Expertise, Federal State Budgetary Educational Institution of Higher Education I.P. Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation, 96 Stroykova Street, Ryazan 390026, Russia.
Received: August 7, 2025
Revised: August 28, 2025
Accepted: December 3, 2025
Published online: January 26, 2026
Processing time: 161 Days and 17.3 Hours
Revised: August 28, 2025
Accepted: December 3, 2025
Published online: January 26, 2026
Processing time: 161 Days and 17.3 Hours
Core Tip
Core Tip: Kounis syndrome type III is a rare but life-threatening condition characterized by stent thrombosis or restenosis caused by allergic reactions to previously implanted coronary stent components, including metallic alloys, polymer coatings, and drugs eluted from the stent surface (e.g., sirolimus). A review of six clinical cases identified predominantly older male patients who uniformly presented with chest pain, while cutaneous rash was infrequent. Medications such as antibiotics and nonsteroidal anti-inflammatory drugs were identified triggers, underscoring the need for careful allergy assessment and prevention strategies.