Huang AX, Xie HY, Luo G, Hong L, Zhou YL, Wang Y, Gao DK. Clinical application and expansion of paclitaxel-coated balloons in coronary atherosclerotic disease. World J Cardiol 2026; 18(1): 108975 [DOI: 10.4330/wjc.v18.i1.108975]
Corresponding Author of This Article
De-Kui Gao, Department of Cardiology, Jiangyou Second People's Hospital, No. 31 Juhui Road, Jiangyou 621701, Sichuan Province, China. 635651229@qq.com
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Cardiac & Cardiovascular Systems
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Review
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 26, 2026 (publication date) through Jan 15, 2026
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Publication Name
World Journal of Cardiology
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1949-8462
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Huang AX, Xie HY, Luo G, Hong L, Zhou YL, Wang Y, Gao DK. Clinical application and expansion of paclitaxel-coated balloons in coronary atherosclerotic disease. World J Cardiol 2026; 18(1): 108975 [DOI: 10.4330/wjc.v18.i1.108975]
World J Cardiol. Jan 26, 2026; 18(1): 108975 Published online Jan 26, 2026. doi: 10.4330/wjc.v18.i1.108975
Clinical application and expansion of paclitaxel-coated balloons in coronary atherosclerotic disease
A-Xiu Huang, Hong-Ying Xie, Gang Luo, Le Hong, Yun-Long Zhou, Yun Wang, De-Kui Gao
A-Xiu Huang, Department of Laboratory Medicine, Jiangyou Second People's Hospital, Jiangyou 621701, Sichuan Province, China
Hong-Ying Xie, Le Hong, De-Kui Gao, Department of Cardiology, Jiangyou Second People's Hospital, Jiangyou 621701, Sichuan Province, China
Gang Luo, Department of Pharmac, Jiangyou Second People's Hospital, Jiangyou 621701, Sichuan Province, China
Yun-Long Zhou, Yun Wang, Department of Oncology, Jiangyou Second People's Hospital, Jiangyou 621701, Sichuan Province, China
Co-first authors: A-Xiu Huang and Hong-Ying Xie.
Author contributions: Huang AX, Xie HY, Gao DK, Zhou YL, and Luo G contributed to the manuscript writing; Gao DK, Xie HY and Huang AX undertook a substantial amount of work in literature retrieval; Huang AX, Xie HY, Gao DK, and Zou YL made contributions to manuscript editing and data analysis; Luo G, Zhou YL, Hong L and Wang Y were involved in data visualization; Gao DK completed the unique thinking and conceptualization of the core issues; and all authors have reviewed and approved the final version submitted. Huang AX and Xie HY are the co-first authors of this work.
Supported by Mianyang Health Commission 2019 Scientific Research Encouragement Project, No. 201948.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: De-Kui Gao, Department of Cardiology, Jiangyou Second People's Hospital, No. 31 Juhui Road, Jiangyou 621701, Sichuan Province, China. 635651229@qq.com
Received: April 30, 2025 Revised: May 30, 2025 Accepted: December 3, 2025 Published online: January 26, 2026 Processing time: 262 Days and 14.9 Hours
Core Tip
Core Tip: Drug-coated balloon (DCB) angioplasty plays a pivotal role in the interventional management of atherosclerotic cardiovascular disease. This review focuses on the application of paclitaxel DCB in coronary artery stenosis, encompassing their use in in-stent restenosis, large or small vessel disease, bifurcation lesions, and other lesion types. Key topics include lesion preparation techniques, DCB delivery strategies, complication management, safety evaluations, and post-procedural dual antiplatelet therapy strategies. Additionally, the review explores cellular and molecular mechanisms underlying anti-atherosclerotic and anti-restenotic effects, including endothelial repair, inhibition of neointimal hyperplasia, and modulation of inflammatory pathways. Current challenges and future directions in optimizing DCB-based therapies are also discussed.
