Zhang JJ, Cheng L, Qiao Q, Xiao XL, Lin SJ, He YF, Sha RL, Sha J, Ma Y, Zhang HL, Ye XR. Adenosine triphosphate-induced cell death in heart failure: Is there a link? World J Cardiol 2025; 17(4): 105021 [DOI: 10.4330/wjc.v17.i4.105021]
Corresponding Author of This Article
Hao-Ling Zhang, PhD, Department of Biomedical Science, Advanced Medical and Dental Institute, University Sains Malaysia, 11800 Gelugor, Pulau Pinang, Penang 13200, Malaysia. zhaohaoling@student.usm.my
Research Domain of This Article
Cell Biology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Apr 26, 2025; 17(4): 105021 Published online Apr 26, 2025. doi: 10.4330/wjc.v17.i4.105021
Adenosine triphosphate-induced cell death in heart failure: Is there a link?
Jing-Jing Zhang, Lu Cheng, Qian Qiao, Xue-Liang Xiao, Shao-Jun Lin, Yue-Fang He, Ren-Luo Sha, Jun Sha, Yin Ma, Hao-Ling Zhang, Xue-Rui Ye
Jing-Jing Zhang, Lu Cheng, Qian Qiao, Xue-Rui Ye, Department of Cardiovascular Medicine, Fuwai Yunnan Hospital, Chinese Academy Medical Sciences, Kunming 650000, Yunnan Province, China
Xue-Liang Xiao, Shao-Jun Lin, Yue-Fang He, Ren-Luo Sha, Jun Sha, Yin Ma, Department of Critical Care Medicine, Ninglang Yi Autonomous County People's Hospital, Lijiang 674300, Yunnan Province, China
Hao-Ling Zhang, Department of Biomedical Science, Advanced Medical and Dental Institute, University Sains Malaysia, Penang 13200, Malaysia
Co-corresponding authors: Xue-Rui Ye and Hao-Ling Zhang.
Author contributions: Zhang JJ, Cheng L, Qiao Q, Xiao XL, Lin SJ and He YF write the first draft of a paper; Sha RL, Sha J and Ma Y make charts and tables. Both Ye XR and Zhang HL have played important and indispensable roles in the conception and manuscript preparation as the co-corresponding authors. Ye XR conceptualized, designed, and supervised the whole process of the project. She searched the literature, revised and submitted the early version of the manuscript with the focus on the association between ATP-induced cell death (AICD) and heart failure. Zhang HL was instrumental and responsible for re-interpretation, figure plotting, comprehensive literature search, preparation and submission of the current version of the manuscript with a new focus on AICD as potential underlying mechanisms. This collaboration between Ye XR and Zhang HL is crucial for the publication of this manuscript and other manuscripts still in preparation.
Supported by Science and Technology Department of Yunnan Province - Kunming Medical University, Kunming Medical Joint Special Project - Surface Project, No. 202401AY070001-164; Yunnan Provincial Clinical Research Center Cardiovascular Diseases - New Technology Research for Development Project for Diagnosis and Treatment Cardiovascular Diseases, No. 202102AA310002; and the Key Technology Research and Device Development Project for Innovative Diagnosis and Treatment of Structural Heart Disease in the Southwest Plateau Region, No. 202302AA310045.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hao-Ling Zhang, PhD, Department of Biomedical Science, Advanced Medical and Dental Institute, University Sains Malaysia, 11800 Gelugor, Pulau Pinang, Penang 13200, Malaysia. zhaohaoling@student.usm.my
Received: January 10, 2025 Revised: February 22, 2025 Accepted: April 2, 2025 Published online: April 26, 2025 Processing time: 102 Days and 7.3 Hours
Core Tip
Core Tip: Heart failure has become a significant worldwide health threat due to its complex pathophysiology and multifactorial causes. Adenosine triphosphate (ATP)-induced cell death is a newly recognized form of regulated cell death, distinct from apoptosis and necrosis, characterized by energy depletion and metabolic disturbances resulting from excessive ATP accumulation. Recent studies indicate that ATP-induced cell death (AICD) is primarily regulated by biological processes involving energy metabolism, redox balance, and intracellular calcium regulation. AICD is vital in heart failure, particularly in situations such as myocardial infarction, ischemia-reperfusion injury, and chemotherapy. Investigating its role in heart failure pathogenesis could provide insights into new therapeutic strategies. This review summarizes recent findings on the link between AICD and heart failure, highlighting its impact on cardiac remodeling and disease progression.
