Wang HN, Wang Y, Zhang SY, Bai L. Emerging roles of the acid sphingomyelinase/ceramide pathway in metabolic and cardiovascular diseases: Mechanistic insights and therapeutic implications. World J Cardiol 2025; 17(2): 102308 [DOI: 10.4330/wjc.v17.i2.102308]
Corresponding Author of This Article
Lan Bai, PhD, Professor, State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Huangjin Campus, University Town, Rongjiang New District, Ganzhou 341000, Jiangxi Province, China. bailan@gmu.edu.cn
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Feb 26, 2025; 17(2): 102308 Published online Feb 26, 2025. doi: 10.4330/wjc.v17.i2.102308
Emerging roles of the acid sphingomyelinase/ceramide pathway in metabolic and cardiovascular diseases: Mechanistic insights and therapeutic implications
Hong-Ni Wang, Ye Wang, Si-Yao Zhang, Lan Bai
Hong-Ni Wang, Ye Wang, Si-Yao Zhang, Lan Bai, State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
Author contributions: Wang HN, Wang Y, and Zhang SY completed the first draft of the paper; Bai L played pivotal roles in the research design, guiding the research group and coordinating the collaborative efforts of all authors, providing detailed guidance, and revising the paper.
Supported by Ganzhou City’s “Light of the Soviet Area” Talent Project, No. GZSQZG202301009.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lan Bai, PhD, Professor, State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Huangjin Campus, University Town, Rongjiang New District, Ganzhou 341000, Jiangxi Province, China. bailan@gmu.edu.cn
Received: October 14, 2024 Revised: December 10, 2024 Accepted: February 8, 2025 Published online: February 26, 2025 Processing time: 133 Days and 17.9 Hours
Core Tip
Core Tip: Metabolic diseases represent a major global public health challenge, and the mechanisms of the acid sphingomyelinase/ceramide (ASMase/Cer) pathway in these diseases remain under-explored. This review synthesizes recent studies on the biological functions, regulatory mechanisms, and targeted therapies associated with the ASMase/Cer pathway in metabolic conditions including obesity, diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular disease. The effects of the ASMase/Cer pathway on glucose-lipid metabolism, insulin resistance, inflammation and mitochondrial homeostasis are elucidated. The insights provided in this review could aid in the development of therapeutic interventions for metabolic diseases and their severe complications.
