Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Nov 26, 2025; 17(11): 112018
Published online Nov 26, 2025. doi: 10.4330/wjc.v17.i11.112018
Published online Nov 26, 2025. doi: 10.4330/wjc.v17.i11.112018
Assessing paclitaxel-coated vs sirolimus-coated balloon angioplasty for coronary artery diseases: A systematic review and meta-analysis
Shree Rath, Department of Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar 751019, Odisha, India
Allahdad Khan, Department of Medicine, Nishtar Medical University, Multan 60650, Punjab, Pakistan
Hamza Khan, Zahir Ud Din, Waseef Ullah, Department of Medicine, Lady Reading Hospital, Peshawar 25000, Pakistan
Asad Ali Ahmed Cheema, Department of Medicine, International School of Medicine, International University of Kyrgyzstan, Bishkek 720000, Kyrgyzstan
Raheel Ahmed, Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
Author contributions: Rath S conceptualized the study, designed the research study, led the study, and was the lead author in performing the analysis, preparing figures, writing the manuscript and revising the final manuscript; Khan A conceptualized the study and was involved in data extraction and writing of the manuscript; Khan H, Cheema AAA, Din ZU, Ullah W, and Ahmed R were involved in data curation and writing of the manuscript; Ahmed R was responsible for the review of the manuscript; and all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shree Rath, MD, Department of Medicine, All India Institute of Medical Sciences Bhubaneswar, Sijua, Patrapada, Bhubaneswar 751019, Odisha, India.
Received: July 16, 2025
Revised: July 28, 2025
Accepted: October 17, 2025
Published online: November 26, 2025
Processing time: 128 Days and 22.3 Hours
Revised: July 28, 2025
Accepted: October 17, 2025
Published online: November 26, 2025
Processing time: 128 Days and 22.3 Hours
Core Tip
Core Tip: This meta-analysis presents the most up-to-date comparison of paclitaxel- vs sirolimus-coated balloon angioplasty for coronary artery disease, encompassing 1981 patients across diverse lesion types. Our findings reveal comparable clinical and angiographic outcomes for both devices but identify a potential advantage for paclitaxel-coated balloons in de novo lesions. These results underscore the need for personalized lesion-specific strategies and highlight the importance of further large-scale trials to refine the role of drug-coated balloons in percutaneous coronary intervention.