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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Oct 26, 2025; 17(10): 112428
Published online Oct 26, 2025. doi: 10.4330/wjc.v17.i10.112428
Published online Oct 26, 2025. doi: 10.4330/wjc.v17.i10.112428
Mortality prediction in ventricular septal rupture at high altitude: A novel tool for resource-limited regions
Kristina G Pereverzeva, Department of Hospital Therapy with a Course in Medical and Social Expertise, Federal State Budgetary Educational Institution of Higher Education I.P. Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation, Ryazan 390026, Ryazanskaya Oblast, Russia
Author contributions: Pereverzeva KG conceptualized, designed, investigated, and wrote the editorial.
Conflict-of-interest statement: The author declare that has no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kristina G Pereverzeva, MD, Associate Professor, Department of Hospital Therapy with a Course in Medical and Social Expertise, Federal State Budgetary Educational Institution of Higher Education I.P. Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation, 96 Stroykova Street, Ryazan 390026, Rya
Received: July 28, 2025
Revised: August 13, 2025
Accepted: September 22, 2025
Published online: October 26, 2025
Processing time: 89 Days and 22.3 Hours
Revised: August 13, 2025
Accepted: September 22, 2025
Published online: October 26, 2025
Processing time: 89 Days and 22.3 Hours
Core Tip
Core Tip: In resource-limited high-altitude regions, ventricular septal rupture complicating myocardial infarction is associated with high mortality rates. Zhang et al developed a nomogram predicting 30-day mortality in patients with ventricular septal rupture, incorporating the following parameters: Age; Uric acid levels; Interleukin-6 and hemoglobin. The model demonstrated high predictive accuracy (area under the curve = 0.939) and enabled timely identification of candidates for emergency surgical intervention. The primary limitation for clinical implementation is the lack of routine interleukin-6 testing availability in most healthcare facilities. Multicenter validation is required prior to adoption in clinical practice.