Saeki Y, Sawaguchi J, Akita S, Takamura TA, Fujibayashi K, Wakasa M, Akao H, Kitayama M, Kawai Y, Kajinami K. Initial decrease in the lipoprotein(a) level is a novel prognostic biomarker in patients with acute coronary syndrome. World J Cardiol 2024; 16(6): 329-338 [PMID: 38993583 DOI: 10.4330/wjc.v16.i6.329]
Corresponding Author of This Article
Kouji Kajinami, FACP, FAHA, MD, Professor, Department of Cardiology, Kanazawa Medical University, 1-1 Daigaku, Uchinada 9200293, Japan. kajinami@kanazawa-med.ac.jp
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Saeki Y, Sawaguchi J, Akita S, Takamura TA, Fujibayashi K, Wakasa M, Akao H, Kitayama M, Kawai Y, Kajinami K. Initial decrease in the lipoprotein(a) level is a novel prognostic biomarker in patients with acute coronary syndrome. World J Cardiol 2024; 16(6): 329-338 [PMID: 38993583 DOI: 10.4330/wjc.v16.i6.329]
Yasuhiko Saeki, Jun Sawaguchi, Satori Akita, Taka-aki Takamura, Kosuke Fujibayashi, Minoru Wakasa, Hironobu Akao, Yasuyuki Kawai, Kouji Kajinami, Department of Cardiology, Kanazawa Medical University, Uchinada 9200293, Japan
Michihiko Kitayama, Trans-catheter Cardiovascular Therapeutics, Kanazawa Medical University, Uchinada 9200293, Japan
Author contributions: Saeki Y contributed to principal investigator (conceptualization, data curation, formal data analysis and interpretation, and drafting of the manuscript); Sawaguchi J contributed to associate investigator (conceptualization, data curation, formal data analysis, and interpretation); Takamura TA, Kitayama M, and Kawai Y contributed to coronary interventionalists (data curation and project administration regarding percutaneous coronary intervention procedures and patient management); Akita S, Fujibayashi K, Wakasa M, and Akao H contributed to staff cardiologists (data curation, preliminary data analysis, and interpretation); Kajinami K contributed to director (supervision of the overall study and manuscript editing/finalization).
Supported bythe Vehicle Racing Commemorative Foundation, No. 2013–2015; Grant for Collaborative Research from Kanazawa Medical University, No. C2015-4; and Grants-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science to Dr. Kouji Kajinami, No. 18K08051 and No. 21K08139.
Institutional review board statement: The study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki and was approved by the Ethics Committee of our institution (Approval No. I-115).
Informed consent statement: Written informed consent was obtained from all patients prior to enrollment.
Conflict-of-interest statement: There are no conflicts of interest to disclose.
Data sharing statement: Data used to support the findings of this study are available from the corresponding author upon request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Corresponding author: Kouji Kajinami, FACP, FAHA, MD, Professor, Department of Cardiology, Kanazawa Medical University, 1-1 Daigaku, Uchinada 9200293, Japan. kajinami@kanazawa-med.ac.jp
Received: February 6, 2024 Revised: April 22, 2024 Accepted: April 28, 2024 Published online: June 26, 2024 Processing time: 140 Days and 5.6 Hours
Core Tip
Core Tip: Two hundred and forty-nine patients with acute coronary syndrome were enrolled in the study. Lipoprotein(a) [Lp(a)] levels were measured before percutaneous coronary intervention (PCI) to 48 h after using an isoform-independent assay. Lp(a) levels decreased significantly from pre-PCI (0 h) to 12 h after, and then increased up to 48 h after. The changes from 0 to 12 h [Lp(a)Δ0-12] were significantly correlated with basal creatinine and Lp(a). Among the tertiles classified according to the changes from 0 to 12 h [Lp(a)Δ0-12], major adverse cardiac events (MACE) were significantly more frequent in the lowest Lp(a)Δ0-12 group than in the other two groups. Multivariate analysis revealed that Lp(a)Δ0-12 and basal creatinine were independent determinants of subsequent MACE.
