Molecular and metabolic landscape of adenosine triphosphate-induced cell death in cardiovascular disease

doi:10.4330/wjc.v16.i12.689

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World Journal of Cardiology

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World J Cardiol. Dec 26, 2024; 16(12): 689-706
Published online Dec 26, 2024. doi: 10.4330/wjc.v16.i12.689

Molecular and metabolic landscape of adenosine triphosphate-induced cell death in cardiovascular disease

Wei Wang, Xue-Mei Wang, Hao-Long Zhang, Rui Zhao, Yong Wang, Hao-Ling Zhang, Zhi-Jing Song

Wei Wang, College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China

Xue-Mei Wang, College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 73000, Gansu Province, China

Hao-Long Zhang, University Sains Malaysia, Advanced Medical and Dental Institute, Penang 13200, Malaysia

Rui Zhao, Zhi-Jing Song, Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China

Yong Wang, Department of Pathology Center, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China

Hao-Ling Zhang, Department of Biomedical Science, Advanced Medical and Dental Institute, University Sains Malaysia, Penang 13200, Malaysia

Co-corresponding authors: Hao-Ling Zhang and Zhi-Jing Song.

Author contributions: Wang W, Wang XM, Zhang HL, Zhao R, and Wang Y completed the first draft of the paper. Zhang HL and Song ZJ played pivotal roles in the research design, guiding the research group and coordinating the collaborative efforts of all authors, providing detailed guidance, and revising the paper; they are co-corresponding author of this manuscript.

Supported by National Natural Science Foundation of China, No. 81960877; University Innovation Fund of Gansu Province, No. 2021A-076; Gansu Province Science and Technology Plan, No. 21JR7RA561; Natural Science Foundation of Gansu Province, No. 21JR1RA267 and No. 24JRRA1020; Education Technology Innovation Project of Gansu Province, No. 2022A-067; Open Project of Key Laboratory of Dunhuang Medicine and Transformation of Ministry of Education, No. DHYX21-07, No. DHYX22-05, and No. DHYX21-01; and Gansu Province Joint Research Fund Project, No. 24JRRA878.

Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.

Corresponding author: Zhi-Jing Song, PhD, Professor, Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, No. 35 Dingxi East Road, Chengguan District, Lanzhou 730000, Gansu Province, China. songzhijing2020@163.com

Received: June 5, 2024
Revised: October 4, 2024
Accepted: November 1, 2024
Published online: December 26, 2024
Processing time: 174 Days and 5.4 Hours

Core Tip

Core Tip: Understanding the mechanisms behind adenosine triphosphate (ATP)-induced cell death (AICD) is crucial for addressing various cardiovascular diseases. AICD, triggered by elevated extracellular ATP levels, differs from other forms of cell death and has emerged as a significant contributor to conditions such as myocardial ischemia-reperfusion injury, sepsis-induced cardiomyopathy, and diabetic cardiomyopathy. This review explores the physiological roles of ATP in the cardiovascular system and delves into the molecular and metabolic mechanisms underlying AICD. Identifying therapeutic targets to mitigate AICD holds promise for treating cardiovascular diseases, although challenges remain. This review provides valuable insights and strategies for preventing and managing cardiovascular disorders.