Xanthopoulos A, Tryposkiadis K, Dimos A, Bourazana A, Zagouras A, Iakovis N, Papamichalis M, Giamouzis G, Vassilopoulos G, Skoularigis J, Triposkiadis F. Red blood cell distribution width in elderly hospitalized patients with cardiovascular disease. World J Cardiol 2021; 13(9): 503-513 [PMID: 34621495 DOI: 10.4330/wjc.v13.i9.503]
Corresponding Author of This Article
Andrew Xanthopoulos, FACC, MD, PhD, Consultant Physician-Scientist, Department of Cardiology, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. andrewvxanth@gmail.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Sep 26, 2021; 13(9): 503-513 Published online Sep 26, 2021. doi: 10.4330/wjc.v13.i9.503
Red blood cell distribution width in elderly hospitalized patients with cardiovascular disease
Andrew Xanthopoulos, Konstantinos Tryposkiadis, Apostolos Dimos, Angeliki Bourazana, Alexandros Zagouras, Nikolaos Iakovis, Michail Papamichalis, Grigorios Giamouzis, George Vassilopoulos, John Skoularigis, Filippos Triposkiadis
Andrew Xanthopoulos, Apostolos Dimos, Angeliki Bourazana, Alexandros Zagouras, Nikolaos Iakovis, Michail Papamichalis, Grigorios Giamouzis, John Skoularigis, Filippos Triposkiadis, Department of Cardiology, University Hospital of Larissa, Larissa 41110, Greece
George Vassilopoulos, Department of Haematology, University of Thessaly Medical School, Larissa 41110, Greece
Author contributions: Xanthopoulos A participated in design of the study, drafted the manuscript, participated in the oversight of the study, and was involved in the data collection; Tryposkiadis K drafted the manuscript and performed the statistical analyses; Dimos A participated in design of the study, and was involved in the data collection; Bourazana A participated in the design of the study, and drafted the manuscript; Zagouras A drafted the manuscript and was involved in the data collection; Iakovis N participated in the design of the study and was involved in the data collection; Papamichalis M was involved in the data collection and drafted the manuscript; Giamouzis G participated, Vassilopoulos G, and Skoularigis J participated in the design and oversight of the study; Triposkiadis F participated in the design and oversight of the study and drafted the manuscript; All authors read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the University General Hospital of Larissa, Larissa, Greece Institutional Review Board.
Informed consent statement: The need for written informed consent was waived by the ethics committee due to the observational nature of the study.
Conflict-of-interest statement: The authors declare no conflict of interest regarding the present work
Data sharing statement: No additional data are available
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Andrew Xanthopoulos, FACC, MD, PhD, Consultant Physician-Scientist, Department of Cardiology, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. andrewvxanth@gmail.com
Received: March 6, 2021 Peer-review started: March 6, 2021 First decision: March 31, 2021 Revised: June 22, 2021 Accepted: August 4, 2021 Article in press: August 4, 2021 Published online: September 26, 2021 Processing time: 195 Days and 19.9 Hours
ARTICLE HIGHLIGHTS
Research background
An increased red blood cell distribution width (RDW) is associated with poor outcomes in patients with several cardiovascular diseases (CVDs).
Research motivation
Data on the pathophysiology of RDW increase in hospitalized patients with CVD are limited.
Research objectives
The current study explored the impact of CV and non-CV coexisting morbidities in elderly patients hospitalized with chronic CVD.
Research methods
This prospective observational study included 204 consecutive elderly (> 65 years) patients admitted to a tertiary university hospital of Greece. Elderly patients were selected due to the high prevalence of coexisting morbidities in this patient population.
Research results
Factors associated with RDW were anemia, acutely decompensated chronic heart failure (ADCHF), and atrial fibrillation (AF).
Research conclusions
ADCHF and AF shared a common characteristic, namely heart rate elevation, which suggests sympathetic nervous system (SNS) overactivity, a well-known regulator of bone marrow.
Research perspectives
Further studies will establish the relationship between RDW and SNS.
