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Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jan 26, 2025; 17(1): 99933
Published online Jan 26, 2025. doi: 10.4330/wjc.v17.i1.99933
Demographic trends in mortality with older population due to atrial fibrillation and flutter from 1999-2020
Mahnoor Sukaina, Marium Waheed, Shafi Rehman, Md Al Hasibuzzaman, Rabab Meghani
Mahnoor Sukaina, Marium Waheed, Department of Internal Medicine, Karachi Medical and Dental College, Karachi 75270, Pakistan
Shafi Rehman, Department of Histopathology, Khyber Medical University, Peshawar, 25000, Pakistan
Md Al Hasibuzzaman, Institute of Nutrition and Food Science, University of Dhaka, Dhaka 1000, Bangladesh
Rabab Meghani, Department of Bioethics, Columbia University, New York, NY 10027, United States
Author contributions: All authors contributed equally in the preparation of the manuscript; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Md Al Hasibuzzaman, MBBS, Researcher, Institute of Nutrition and Food Science, University of Dhaka, Suhrawardi Udyan Road, Dhaka 1000, Bangladesh. al.hasibuzzaman.hasib@gmail.com
Received: August 3, 2024
Revised: December 7, 2024
Accepted: January 7, 2025
Published online: January 26, 2025
Processing time: 171 Days and 0.2 Hours
Abstract

Atrial fibrillation (AF)/atrial flutter (AFL) is the most common sustained cardiac arrhythmia. The known risk factors for developing AF/AFL include age, structural heart disease, hypertension, diabetes mellitus, or hyperthyroidism. This study aims to attribute the trends in AF/AFL-related mortalities over the past two decades 1999-2020 concerning race and sex and disparity among them. To the best of our knowledge, this is the first study that estimates the trends and mortality due to AF/AFL from 1999-2020 in older adults in the United States. In this 21-year analysis of mortality data, we found a constant increase in mortality rates due to AF/AFL in older adults. From 1999 to 2020, the overall mortality in older adults aged 65 and above, regardless of sex and race, is found to be almost doubled i.e. about a 50.2% increase in the number of deaths due to AF/AFL. Furthermore, other confounding risk factors such has obesity, prior myocardial infarction, inflammation, hypertension, birth weight, diabetes mellitus, hyperthyroidism, hormone replacement therapy in menopausal women increases the risk in the occurrence or recurrent occurrence of AF.

Keywords: Demographic trends; United States; Atrial fibrillation; Atrial flutter; Older population

Core Tip: This research discusses atrial fibrillation and flutter-related mortality in an older population, of the United States, using the nationwide Centers for Disease Control and Prevention database. The paper further demonstrates the trend analysis of demographic factors from 1999 to 2020.