CD36 fatty-acid-transporter gene variants-CD36 G/A (rs1761667) and CD36 C/T (rs75326924) as biomarkers for risk-prediction in gestational diabetes mellitus

Table 1 Details of anthropometric parameters of controls and gestational diabetes mellitus cases, n (%)

Parameters	Controls (n = 200)	GDM (n = 200)	P value
Anthropometric parameters (mean ± SD)
Age (years)	26.74 ± 5.3	29.39 ± 5.7	0.0003a
Gestational age	24.74 ± 3.9	25.65 ± 2.5	0.0077a
Family history of diabetes
Yes	41 (19.3)	88 (43.3)	0.0001a
No	159 (80.7)	112 (56.7)
Body mass index (kg/m2)	23.97 ± 2.67	25.98 ± 2.38	0.0001a
Systolic blood pressure	124.3 ± 7.73	126.8 ± 9.98	0.0066a
Diastolic blood pressure	79.08 ± 6.44	81.39 ± 8.28	0.0020a
Biochemical parameters (mean ± SD) (mg/dL)
Fasting plasma glucose	84.2 ± 4.2	99.9 ± 4.5	0.0001a
Post prandial glucose	125.7 ± 24.57	159.9 ± 36.11	0.0001a
Total cholesterol	176.7 ± 14.3	182.2 ± 22.2	< 0.091
Triglycerides	154.7 ± 20.36	181.5 ± 30.47	0.0001a
High-density lipoprotein	51.7 ± 7.5	50.3 ± 6.9	0.0835
Low-density lipoprotein	69.53 ± 16.19	76.49 ± 22.96	0.0027a
Serum creatinine	0. 09 ± 0.7	1.1 ± 0.5	0.0828

^aP < 0.05 showed association with gestational diabetes mellitus.

Data are represented as mean ± SD. GDM: Gestational diabetes mellitus.

Table 2 Genotypic and allelic frequencies of CD36 (rs1761667) (G/A) and (rs75326924) (C/T) polymorphisms in healthy pregnant controls (n = 200) and gestational diabetes mellitus cases (n = 200)

Genotype frequency
Genotype	Control, n = 200 (%)	Case, n = 200 (%)	P value	Odd ratio 95%CI
CD36 (rs1761667)
GG	96 (44)	64 (32)	-	1.0 (Refence)
GA	58 (29)	102 (51)	0.0001	2.638 (1.695-4.190)
AA	46 (23)	34 (17)	0.7103	1.109 (0.6386-1.895)
Allelic frequency
G	250 (62.5)	230 (57.5)	0.1489	1.232 (0.9297-1.635)
A	150 (37.5)	170 (42.5)
Carriage rate
G+	154 (77)	166 (83)	0.1336	0.6857 (0.4182-1.133)
G-	46 (23)	34 (17)
A+	104 (52)	136 (68)	0.0011	0.5098 (0.3428-0.7628)
A-	96 (480	64 (32)
CD36 (rs75326924)
CC	114 (57)	82 (41)	-	1.0 (Refence)
CT	55 (27.5)	80 (40)	0.0025	2.022 (1.279-3.164)
TT	31 (15.5)	38 (19)	0.678	1.704 (0.980-2.918)
Allelic frequency
C	283 (70.75)	244 (61)	0.0046	1.546 (1.156-2.081)
T	117 (29.25)	156 (39)
Carriage rate
C+	169 (84.5)	162 (81)	0.4273	1.279 (0.754-2.129)
C-	31 (15.5)	38 (19)
T+	86 (43)	118 (59)	0.0019	0.524 (0.352-0.786)
T-	114 (57)	82 (41)